Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

By J. Chan, Susanna K. P. Lau, K. To, V. Cheng, Patrick C. Y. Woo, Kwok-Yung Yuen. Clinical Microbiology Reviews, 2015

811 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/a43b46e0519671e5de823cf2a8a8ffafdf4f5aea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. Abdo A. Elfiky
2. Kwok-Yung Yuen
3. Ralph S. Baric
4. Kwok-Hung Chan
5. Rachel L. Graham
6. H. Tsoi

In Infectious Diseases

1. Abdo A. Elfiky
2. Kwok-Yung Yuen
3. J. Chan
4. K. To
5. V. Cheng
6. Kwok-Hung Chan
7. Ralph S. Baric
8. Shuofeng Yuan

Citations in the corpus

• SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective (2020, background): “SARS-CoV-2 is a Betacoronavirus like the SARS and MERS human coronaviruses (Chan et al., 2015; Elfiky et al., 2017; Ibrahim et al., 2020).”
• Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset (2015, background): “We have previously demonstrated the in vivo treatment effects of lopinavir/ritonavir in SARS patients.”
• A Review of SARS-CoV-2 and the Ongoing Clinical Trials (2020, background): “The imaging findings of COVID-19 pneumonia mimic influenza, SARS-CoV, and MERS-CoV pneumonia [11] [12] [13] [14] [15] .”
• Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020, background): “The best-known examples include severe acute respiratory syndrome CoV (SARS-CoV) which emerged in China in 2002-2003 to cause a large-scale epidemic with about 8000 infections and 800 deaths, and Middle East respiratory syndrome CoV (MERS-CoV) which has caused a persistent epidemic in the Arabian Pe”
• Coronavirus disease 2019: What we know? (2020, background): “the past 2 decades, two novel CoVs, severe acute respiratory syndrome CoV (SARS‐CoV) and Middle East respiratory syndrome CoV (MERS‐CoV), have emerged and cause severe human diseases.(8,9) During the epidemic, SARS‐CoV infect more than 8000 people worldwide with nearly 800 fatalities, representing i”
• Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens (2020, background): “Traditionally, the preferred targets of coronavirus RT-PCR assays included the conserved and/or abundantly expressed genes such as the structural S and N genes and the nonstructural RdRp and replicase open reading frame (ORF) 1a/b genes (16, 28) .”
• Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease (2018, background): “Supportive care and prevention of complications constitute the current standard of treatment for patients, emphasizing the need for direct-acting antivirals (8, 9).”
• Coronavirus Disease 2019 (COVID-19): A Perspective from China (2020, background): “ARDS= acute respiratory distress syndrome COVID-19 = Coronavirus Disease 19 GGO = ground-glass opacity MERS = Middle East respiratory syndrome RT-PCR = reverse-transcription–polymerase-chain-reaction SARS = severe acute respiratory syndrome SARS-CoV-2 = severe acute respiratory syndrome coronavirus ”
• Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study (2020, background): “1 On Dec 31, 2019, WHO was informed of a cluster of unexplained cases of pneumonia in Wuhan, Hubei province, China.”
• Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016, methodology): “In the case of MERS-CoV, studies in Oman, Saudi Arabia, Qatar, United Arab Emirates, and Jordan have shown that dromedary camels are seropositive for neutralizing antibodies against MERS-CoV [54], as well as camels of Middle East origin in Africa, including Egypt, Kenya, Nigeria, Ethiopia, Tunisia, ”