Feature-based prediction of non-classical and leaderless protein secretion.

By Jannick Dyrløv Bendtsen, Lars Juhl Jensen, Nikolaj S. Blom, G. von Heijne, Søren Brunak. Protein engineering, design & selection : PEDS, 2004

1,142 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0e8b1d97eab516c7037aa25521b9db031553712

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In Immunology

1. Sudipto Saha
2. Richard J. Simpson
3. Gajendra P. Raghava
4. Suresh Mathivanan
5. Arnold J. Levine
6. Manoj Bhasin

In Molecular Biology

1. Burkhard Rost
2. Henrik Nielsen
3. Rajesh Nair
4. Gajendra P. Raghava
5. Piero Fariselli
6. Hina Kalra
7. Pier Luigi Martelli
8. Rita Casadio

Citations in the corpus

• BaCelLo: a balanced subcellular localization predictor (2006, background): “Furthermore some proteins are translocated into mitochondria owing to a localization peptide at the C-terminal region (Lee et al ., 1999; Izeta et al ., 2003; Yamada et al ., 2004).”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “, 1994); the underlined sequence represents the predicted secretion signal peptide motif (Bendtsen et al., 2004).”
• Mimicking cellular sorting improves prediction of subcellular localization. (2005, background): “they do not possess N-terminal signal peptides.(38,39) Furthermore, a particular problem for methods detecting N-terminal signals is that start codons are predicted with less than 70% accuracy by genome projects.”
• Locating proteins in the cell using TargetP, SignalP and related tools (2007, background): “In eukaryotes, a few proteins are secreted without an SP through the so-called non-classical pathway, which does not follow the classical route through the ER and Golg”
• The regulation of exosome secretion: a novel function of the p53 protein. (2006, background): “Maspin can be identified as a secreted protein without a signal sequence (25) and has been shown to have an uncleaved facultative secretion signal that allows small amounts of the protein to be secreted via the endoplasmic reticulum/Golgi pathway (26), however, the CyPA, PRDX-1, PGK1, Eno1, translat”
• ExoCarta as a resource for exosomal research (2012, background): “Gyorgy et al. reported that 30% of cytoplasmic proteins identified in exosomes were predicted to be secreted by non-classical secretory pathways [SecretomeP (37)].”
• AlgPred: prediction of allergenic proteins and mapping of IgE epitopes (2006, methodology): “A different approach to minimize similarity between proteins used for training and testing without reducing total number of proteins has been used in this study (26).”