Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors.
By Hélène Salmon, K. Franciszkiewicz, D. Damotte, M. Dieu-Nosjean, P. Validire, A. Trautmann, F. Mami-Chouaib, E. Donnadieu. Journal of Clinical Investigation, 2012
916 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/41ab767ff2a9b1f6520a6db972be60d5473962f3
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In Oncology
Citations in the corpus
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “The phenomenon could be observed in several results [313, 463, 464].”
- Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment (2018, background): “Knowing the detrimental effect of tumor fibrosis on the capacity of T cells to infiltrate tumor islets (10, 11, 32), we initially thought that TAM depletion would have led to a reduction in ECM fiber deposition.”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Increased collagen deposition surrounding tumor cell clusters in lung tumors and pancreatic cancers was observed to restrict T lymphocyte access to contacting cancer cells [281, 282].”
- Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy (2020, background): “showed in human lung tumor specimen that the migration and finally distribution of T cells is dictated by the aligned collagen fibers surrounding tumor islets and perivascular regions in the tumor stroma (Salmon and Donnadieu, 2012; Salmon et al., 2012).”
- Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. (2020, background): “The dense networks of CAF-secreted collagen fibers in tumor nests have been shown to constitute a physical barrier that prevents T cells from reaching the tumor bed (61).”