The biochemistry of apoptosis

By Michael O. Hengartner. Nature, 2000

7,682 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/36d9cabf862460ceed2ebd1b03cec738f5462846

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Citations in the corpus

The Role of Resveratrol in Cancer Therapy (2017, background): “Apoptotic cells can be identified by regular biochemical and morphological properties, including membrane blebbing, cell shrinkage, nuclear DNA fragmentation, chromatin condensation, and formation of apoptotic bodies [95].”
A common coding variant in CASP8 is associated with breast cancer risk (2007, background): “Caspase-8 is an important initiator of apoptosis (programmed cell death) and is activated by external death signals and in response to DNA damag”
Apoptosis: A Review of Programmed Cell Death (2007, background): “Biochemical Features: Apoptotic cells exhibit several biochemical modifications such as protein cleavage, protein cross-linking, DNA breakdown, and phagocytic recognition that together result in the distinctive structural pathology described previously (Hengartner, 2000).”
Exposure to solar radiation increases damage to both host tissues and algal symbionts of corals during thermal stress (2004, background): “Although apoptosis is a well-described regulatory phenomenon during embryonic development and plays a significant role in the biology of cancer, recent interest has focused on its role in the eukaryotic stress response (Hengartner 2000).”
DAI complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA (2012, neutral): “Apoptosis is a well-recognized caspase-dependent host defense pathway triggered through cell-intrinsic as well as cell-extrinsic signals that also helps shape embryonic development (Hengartner, 2000; Strasser et al., 2000).”
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. (2010, background): “The swelling of mitochondria is an indicator of outer membrane rupture [47].”
Inter-nucleosomal DNA fragmentation and loss of RNA integrity during seed ageing (2010, background): “Nucleolytic events such as DNA laddering and rRNA degradation are known characteristics of PCD that have been extensively studied in human and animal tissues (Chowdhury et al. 2006; Hengartner 2000; Raff 1998) and”
Mechanisms of ischemic brain damage. (2008, neutral): “The anti-apoptotic Bcl-2 proteins, Bcl-2 and Bcl-XL, can form heterodimers with Bax, thereby preventing pore formation (Edwards and Dean, 1977; Miyashita and Reed, 1995; Hengartner, 2000; Kroemer and Reed, 2000; Adams and Cory, 2001; Antonsson et al., 2001).”
GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer (2009, background): “As it is now generally accepted that apoptosis plays an essential role in many physiological processes, from cell turnover in most tissues to the removal of hormone-dependent cells (Warri et al., 1993; Hale et al., 1996; Hengartner, 2000), failure of apoptosis is inevitably of great significance.”
Mechanisms of cell protection by heme oxygenase-1. (2010, background): “Binding of cytochrome c to the apoptotic peptidase-activating factor-1 (Apaf-1) leads to the formation of the apoptosome, a cytosolic multiprotein complex in which caspase-9 is activated (reviewed in 100), which in turn induces the activation of effector caspases, for example, caspase-3 (71).”