Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.

By K. Huber, M. Kayser, Mark F. Bear. Science, 2000

997 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/36a3a236f20fa5136e2bba12f3d17466e0d5ddde

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Malenka
2. A. Citri
3. Nahum Sonenberg
4. E. Schuman
5. Richard L. Huganir
6. C. Bramham
7. Y. Dan
8. S. Tonegawa

In Molecular Biology

1. C. Bramham
2. Mauro Costa-Mattioli
3. D. Wells
4. Nahum Sonenberg
5. E. Schuman
6. R. Malenka
7. E. Klann
8. A. Citri

In Neurology

1. Nahum Sonenberg
2. A. Citri
3. Masao Ito
4. E. Schuman
5. C. Bramham
6. D. Wells
7. Mustafa Sahin
8. O. Steward

Citations in the corpus

• Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “Indeed, a transgene lacking the transmembrane domains could rescue LTD (Kakegawa et al., 2007b), suggesting that GluD2 might function as a scaffolding protein rather than an ionotropic receptor.”
• Spike timing-dependent plasticity: from synapse to perception. (2006, result): “This model is consistent with the finding of a mGluR-dependent form of homosynaptic LTD in the hippocampus induced by both low-frequency stimulation (47, 84) and post-pre spiking (82).”
• Protein synthesis at synaptic sites on dendrites. (2001, methodology): “Capitalizing on the link between mGluR activity and stimulation of dendritic protein synthesis, Bear and colleagues examined whether mGluR-dependent LTD requires protein synthesis that is local (Huber et al 2000).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “…translation: mGluR-LTD and L-LTP induced by pairing E-LTPinducing stimulation (normally protein synthesis independent) with activation of b-adrenergic receptors are dependent on local dendritic protein synthesis, but not on new gene expression (Gelinas and Nguyen, 2005; Huber et al., 2000).”
• Translational regulatory mechanisms in persistent forms of synaptic plasticity. (2004, background): “have been excised continue to support the full expresHow diverse is the repertoire of proteins synthesized sion of LTD (Huber et al., 2000).”
• The autistic neuron: troubled translation? (2008, background): “The discoveries that BDNF-induced LTP and mGluR-dependent LTD, both of which require protein synthesis, can be supported by isolated dendrites further suggested a crucial role for translational upregulation in response to synaptic activity (Kang and Schuman, 1996; Huber et al., 2000).”
• Correction of fragile X syndrome in mice. (2007, background): “…mGluR1 and mGluR5 (Weiler and Greenough, 1993); (3) many of the lasting consequences of activating Gp1 mGluRs depend on synaptic mRNA translation (Huber et al., 2000; Karachot et al., 2001; Merlin et al., 1998; Raymond et al., 2000; Vanderklish and Edelman, 2002; Zho et al., 2002); and (4)…”
• The Neurology of mTOR (2014, positive): “Consistently, inhibition of protein synthesis or mTOR signaling blocks mGluR-dependent LTD (Auerbach et al., 2011; Banko et al., 2006; Hou and Klann, 2004; Huber et al., 2000).”
• Metabotropic glutamate receptors: From the workbench to the bedside (2010, background): “This form of synaptic plasticity can also be induced by synaptic activity and has been shown to be dependent on dendritic protein synthesis under certain circumstances (Huber et al., 2000) but independent of protein synthesis under others (Moult et al., 2008).”
• Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. (2006, background): “Long-term maintenance of LTP and LTD requires new protein synthesis (Huber et al., 2000; Nguyen and Kandel, 1996; Otani and Abraham, 1989), and both LTP- and LTD-inducing stimuli enhance the production of an overlapping set of proteins through shared biochemical pathways such as the MAPK cascade…”
• Mutations causing syndromic autism define an axis of synaptic pathophysiology (2011, background): “A sensitive electrophysiological read-out of local mRNA translation in response to mGluR5 activation is long-term synaptic depression (LTD) in area CA1 of the hippocampu”
• Fragile X Mental Retardation Protein: A Paradigm for Translational Control by RNA-Binding Proteins (2015, background): “Metabotropic glutamate receptor (mGluR) LTD is a major form of LTD, which depends on local protein synthesis at the synapse and leads to the internalization of α-amino-3hydroxyl-4-isoxazole propionic acid (AMPA) receptors (Carroll et al., 1999; Huber et al., 2000; Kemp and Bashir, 1999).”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Another important feature of mGluR LTD, at least in the hippocampus, is that it appears to be dependent on mGluRtriggered protein synthesis (Hou and Klann, 2004; Huber et al, 2000, 2001; Snyder et al, 2001).”