The Neurology of mTOR
By J. Lipton, Mustafa Sahin. Neuron, 2014
692 citations recorded by the source corpus.
The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance. The importance of mTOR signaling to brain function is underscored by the myriad disorders in which mTOR pathway dysfunction is implicated, such as autism, epilepsy, and neurodegenerative disorders. Pharmacological manipulation of mTOR signaling holds therapeutic promise and has entered clinical trials for several disorders. Here, we review the functions of mTOR signaling in the normal and pathological brain, highlighting ongoing efforts to translate our understanding of cellular physiology into direct medical benefit for neurological disorders.
Subfields: Genetics, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/c2557b2bda06e6215372a68da2bf697b1301f40d
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Citations in the corpus
- mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “Brain function mTOR has also emerged as an important regulator of numerous neurological processes including neural development, circuit formation, and the neural control of feeding (reviewed in Lipton and Sahin, 2014).”
- mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “mTOR has also emerged as an important regulator of numerous neurological processes, including neural development, circuit formation, and the neural control of feeding (reviewed in Lipton and Sahin, 2014).”
- Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “186 Ablation of Rictor or Raptor in neurons was found to decrease the neuron size and early death.”