Protein synthesis at synaptic sites on dendrites.
By O. Steward, E. Schuman. Annual Review of Neuroscience, 2001
730 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/1b6195d657653124313e50398c332ff1964641d7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
- Nahum Sonenberg
- R. Malenka
- S. Tonegawa
- Joseph E LeDoux
- A. Citri
- E. Kandel
- Gina G. Turrigiano
- E. Schuman
In Molecular Biology
- R. Malenka
- Nahum Sonenberg
- Mauro Costa-Mattioli
- Mark F. Bear
- E. Klann
- Wayne S. Sossin
- A. Citri
- R. J. Kelleher
Citations in the corpus
- Dynamic visualization of local protein synthesis in hippocampal neurons. (2001, neutral): “In most untreated neurons, expreslasting synaptic plasticity (reviewed in Schuman, 1999a; sion of the reporter was robust in the cell bodies and Steward and Schuman, 2001; Wells et al., 2000).”
- Translational control of long-lasting synaptic plasticity and memory. (2009, positive): “…components of the protein synthesis machinery, including ribosomes, translation factors, and mRNAs, are present in dendrites and dendritic spines (Steward and Schuman, 2001; Sutton and Schuman, 2006), it was also posited that long-lasting plasticity could be engendered through the activation of…”
- The mGluR theory of fragile X mental retardation. (2004, positive): “Emerging functions of Gp1 mGluR-stimulated protein synthesis It has been recognized for many years that the machinery for protein synthesis is present in the dendrites of cortical neurons near synapses [ 53 ,54].”
- The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “Besides this long route of communication by transduction signals that move all the way from the synapse to the nucleus in the somatic region of the neuron, the presence of mRNAs and ribosomal protein synthesis machinery within synaptic locations in the dendrites could enable the activity-dependent, ”
- NMDA receptors, place cells and hippocampal spatial memory (2004, background): “Additional regulation can also occur at the level of mRNA transport and translatio”
- Dendritic protein synthesis, synaptic plasticity, and memory. (2006, methodology): “Currently, lists range from 40–400 candidates (e.g., Eberwine et al., 2001; Steward and Schuman, 2001; Zhong et al., 2006) depending on the methods employed for mRNA detection.”
- The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP (2011, methodology): “However, an alternative model combining STC with the phenomenon of local activity-induced protein synthesis (Martin and Kosik, 2002; Steward and Schuman, 2001), namely the Clustered Plasticity Hypothesis (CPH) (Govindarajan et al.”
- Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. (2004, background): “Since mRNA for the CaMKII isoform is present in dendrites, while mRNA for the isoform is absent, local translation in response to NMDAR activity has been proposed to regulate synaptodendritic levels of CaMKII (Steward and Schuman, 2001).”