The ADAMTS metalloproteinases.

By S. Porter, I. Clark, L. Kevorkian, D. Edwards. 2005

807 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Immunology and Allergy

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Khalil
2. C. Malemud
3. Hideaki Nagase
4. D. Edwards
5. S. Zhong
6. C. López‐Otín
7. C. Brinckerhoff
8. K. Brew

In Hematology

1. Hideaki Nagase
2. C. Malemud
3. R. Khalil
4. S. Zhong
5. D. Edwards
6. A. Colige
7. M. Bekhouche
8. C. López‐Otín

In Immunology and Allergy

1. S. Apte
2. S. Zhong
3. R. Khalil
4. Alexandra Naba
5. M. Bekhouche
6. A. Colige
7. R. Hynes
8. K. Alitalo

Citations in the corpus

• A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “A similar autocatalytic activation process has been reported for ADAMTS-1, 4, 8, 9 and 12 [42], suggesting that this autocatalytic activation and regulation could be a common feature of most ADAMTS proteases [41].”
• Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice (2016, neutral): “*p % 0.05; **p % 0.01; ***p % 0.001. severe skin fragility and joint laxity (hyperextensibility) (Porter et al., 2005).”
• CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation (2014, background): “Apart from ADAMTS3, 2 other proteases, ADAMTS2 and ADAMTS14, belong to the procollagenase subfamily of ADAMTS proteases.(24) Interestingly, the ADAMTS1 gene deletion in mice results in deficient ovarian lymphangiogenesis.”
• ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells (2010, background): “Several ADAM/ ADAMTS enzymes have roles in cell differentiation and cell guidance mechanisms during development [2,3].”
• Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction (2015, neutral): “However, the relevance of the ADAMTS family to cardiovascular disease remains largely unknown [10].”
• The ADAM metalloproteinases (2008, background): “The disintegrin domain is followed in the ADAMs by the cysteine-rich domain, which is also seen in the SVMPs and ADAMTSs, though in the latter the first of a series of C-terminal thrombospondin-like repeats is interposed (Porter et al., 2005).”
• The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology. (2015, methodology): “A similar activation process was also reported for ADAMTS1, 4, 8, 9 and 12 [20], suggesting that this step of regulation could be a common feature of the ADAMTS proteases.”
• Matrix metalloproteinases (MMPs) in health and disease: an overview. (2006, background): “Although MMP-3 (stromelysin-1) is capable of degrading cartilage proteoglycans, ADAMTS-4 and -5 appear to be the main mediators of aggrecan degradation in RA and OA (38, 39).”
• What is Intervertebral Disc Degeneration, and What Causes It? (2006, background): “Disc cells synthesize their matrix and break down existing matrix by producing and activating degradative enzymes, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAMS).[14-20] Molecular markers of matrix turnover are naturally most plentiful during growth but us”
• Emerging roles of proteases in tumour suppression (2007, background): “ADAMTSs These are members of a family that includes 19 human enzymes, which show some structural relationships with other metallo-proteinases such as MMPs and ADAMs (disintegrin and metalloproteinase domain proteases”
• The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family (2015, background): “Once again, versican heterozygosity exacerbated the phenotype seen with mice deficient in ADAMTS20 Table 1 ADAMTS genes: their chromosomal positions, major tissue expression locations, expression-inducing factors bstrates, and associations with pathologies Gene Location Expression Factors inducing o”
• Knockout of Adamts7, A Novel CAD Locus in Humans, Reduces Atherosclerosis in Mice (2015, neutral): “specificity.(8,9) Previous research on ADAMTS7 has centered”
• Matrix metalloproteinases: role in arthritis. (2006, background): “Their enzymatic activities are varied and include cleaving collagen propeptides, inhibiting angiogenesis, and degrading cartilage proteoglycans (33).”
• Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase‐1) in osteoarthritic chondrocytes (2008, background): “8, 9 and 15 are known to exhibit the signature aggrecanase activity (cleavage at the Glu(392)–Ala(393) bond) [1,2].”