Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction
By Wen-jing Wu, Yifeng Zhou, Yiyang Li, Jia-hui Li, Yuannan Ke, Yong Wang, Jingang Zheng. 2015
25 citations recorded by the source corpus.
BackgroundThe metalloproteinase family of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) degrades extracellular matrix. However, the relevance of the ADAMTS family to cardiovascular diseases remains largely unknown. The study aimed to examine plasma ADAMTS-7 levels in patients with acute myocardial infarction (AMI) and the relationship between plasma ADAMTS-7 levels and heart function.MethodsThis was a prospective study performed in 84 patients with ST-elevation myocardial infarction (STEMI), 70 patients with non-STEMI (NSTEMI), and 38 controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma ADAMTS-7 levels. Cardiac structure and function were assessed using two-dimensional transthoracic echocardiography. Patients were stratified according to left ventricular ejection fraction (LVEF) ≤35% or >35%.ResultsPlasma ADAMTS-7 levels were higher in patients with LVEF ≤35% compared with those with LVEF >35% (6.73 ± 2.47 vs. 3.22 ± 2.05 ng/ml, P < 0.05). Plasma ADAMTS-7 levels were positively correlated with brain natriuretic peptide (BNP), left ventricular mass index (LVMI), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-systolic diameter (LVESD) and negatively correlated with the 6-min walk test (P < 0.05). According to the receiver operating characteristic (ROC) curve, using a cutoff value of plasma ADAMTS-7 of 5.69 ng/ml was associated with a specificity of 61.0% and a sensitivity of 87.6% for the diagnosis of heart failure after AMI. Logistic regression analysis indicated that the association between ADAMTS-7 and heart failure after AMI was independent from traditional cardiovascular risk factors and other biomarkers (odds ratio = 1.236, 95% confidence interval: 1.023 to 1.378, P = 0.021).ConclusionsElevated ADAMTS-7 level may be involved in ventricular remodeling after AMI.
Subfields: Cancer Research, Immunology and Allergy, Rheumatology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Immunology and Allergy
In Rheumatology
Citations in the corpus
- A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “Plasma ADAMTS-7 levels have also been associated with ventricular remodeling in patients with acute myocardial infarction [160].”
- ADAMTS proteins in human disorders (2018, background): “Plasma levels of ADAMTS7 were elevated in patients with diminished left ventricular ejection fraction, an indicator of poor ventricular contraction [83, 84].”
- Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease (2016, background): “Logistic regression analysis indicated that the association between ADAMTS-7 and heart failure after AMI was independent from traditional cardiovascular risk factors and other biomarkers.([18]) Pioneering research has also shown ADAMTS-7 accelerated vascular smoothmuscle cellmigration([19]) and inhi”