The Multifaceted Contributions of Mitochondria to Cellular Metabolism

By J. Spinelli, M. Haigis. Nature Cell Biology, 2018

1,535 citations recorded by the source corpus.

Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how mitochondria catabolize nutrients for energy, generate biosynthetic precursors for macromolecules, compartmentalize metabolites for the maintenance of redox homeostasis and function as hubs for metabolic waste management. We address the importance of these roles in both normal physiology and in disease.

Subfields: Cancer Research, Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/34ccb7994b9f5158a07c5aebd168839ff3256cea

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Citations in the corpus

Nanomedicine in cancer therapy (2023, background): “390 Paradoxically, mitochondria also are suicide weapon store of the eukaryotic cell.”
Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “274 281 Furthermore, alterations in mitochondrial dynamics and quality control mechanisms, as well as increased ROS production, contribute to a vicious cycle that exacerbates both mitochondrial dysfunction and metabolic syndrome.”
Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity (2020, background): “A hallmark feature of tumor cell metabolism is increased nutrient consumption tomeet energetic, anabolic, and pro-survival demands (Pavlova and Thompson, 2016; Spinelli and Haigis, 2018).”
Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “In addition, mitochondria play an important role in maintaining ion homeostasis, ROS clearance, the stress response, and serve to integrate multiple signaling pathways [116,117].”
Molecular mechanisms and physiological functions of mitophagy (2021, positive): “Mitochondria are double-membrane-bound subcellular compartments that function in fundamental processes such as ATP production, phospholipid biosynthesis/transport, calcium signaling, and iron homeostasis (Raffaello et al , 2016; Tamura & Endo, 2017; Spinelli & Haigis, 2018).”