Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.

By Y. Hayashi, Song-Hai Shi, J. Esteban, Antonella Piccini, J. Poncer, R. Malinow. Science, 2000

1,615 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/34c5cfae81fe80606953de1fa08daecd6d3413fa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Malenka
2. Gina G. Turrigiano
3. Y. Dudai
4. Richard L. Huganir
5. R. Nicoll
6. A. Citri
7. M. Sheng
8. E. Kandel

In Molecular Biology

1. R. Malenka
2. R. Nicoll
3. Gina G. Turrigiano
4. Richard L. Huganir
5. M. Sheng
6. A. Citri
7. Y. Dudai
8. R. Malinow

Citations in the corpus

• Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. (2003, background): “…activityefficacy, as the insertion and internalization of AMPARs and consequently stimulates actin filament turnovermediate LTP and long-term depression (LTD), respec(Carlier and Pantaloni, 1997; Chen et al., 2000; Pantalonitively (Carroll et al., 2001; Hayashi et al., 2000; Lledo et et al., 2001).”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Based on clever overexpression studies, one prominent hypothesis suggests that subunit-specific rules govern the synaptic delivery of AMPARs (Hayashi et al, 2000; Passafaro et al, 2001; Shi et al, 2001).”
• The molecular and systems biology of memory. (2014, positive): “…phase of LTP involves activation of second messengers that leads to an increase in the incorporation of new AMPA type glutamate receptors into the synapse resulting in a strengthened response (Hayashi et al., 2000; Shi et al., 2001; Shi et al., 1999; Granger et al., 2013; Malinow et al., 2000).”
• Silent synapses and the emergence of a postsynaptic mechanism for LTP (2008, background): “The simplest mechanism for the rapid appearance of AMPARs at the postsynaptic membrane following an LTP protocol is a physical movement of heteromeric receptor complexes to the postsynaptic densit”
• AMPA receptor trafficking at excitatory synapses. (2003, background): “Since SAP-97 is the only protein known to bind to the PDZ domain of GluR1, it will be of phosphorylates an unknown protein that in turn interacts with the PDZ motif of GluR1 (Hayashi et al., 2000; Shi et interest to examine further the possible role of SAP97 in LTP and determine if other scaffolding”
• Structural and molecular remodeling of dendritic spine substructures during long-term potentiation (2014, background): “In the CA1 region of the hippocampus, LTP is initiated by the entry of Ca2+ through NMDA-type glutamate receptors (NMDARs), which triggers the translocation of specific proteins to the synapse, including AMPA-type glutamate receptors (AMPARs; Hayashi et al., 2000).”
• APP processing and synaptic function. (2003, positive): “Here, we show that neuronal activity regulates Sindbis expression system (Hayashi et al., 2000; Schlesinger and Dubensky, 1999; Shi et al., 1999; Zhu et al., the production and secretion of A by controlling APP processing upstream of -secretase activity. In addition, 2000) to acutely deliver APP and”
• Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach (2009, positive): “Based on a variety of experiments in which GluA subunits were overexpressed in culture preparations, a leading model for constitutive and activity-dependent AMPAR trafficking has been advanced ( Hayashi et al., 2000; Malinow and Malenka, 2002; Passafaro et al., 2001; Shi et al., 2001).”