AMPA receptor trafficking at excitatory synapses.

By D. Bredt, R. Nicoll. Neuron, 2003

1,166 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/a539b9a2d00f785db49e3c1fc41bd093d47a32db

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Citations in the corpus

Neuronal circuitry for pain processing in the dorsal horn (2010, background): “Hippocampal LTP is thought to involve insertion of AMPARs containing either GluA1 or GluA4 subunits into glutamatergic synapses, leading to increased postsynaptic responses to glutamat”
Abundant distribution of TARP γ‐8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites (2006, background): “…dynamic changes by endocytosis–exocytosis and by lateral movement from extrasynaptic to synaptic sites, which are thought to underlie activitydependent neural plasticity and developmental synapse maturation (Sheng & Lee, 2001; Malinow & Malenka, 2002; Song & Huganir, 2002; Bredt & Nicoll, 2003).”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Transport of NMDAR and AMPAR is regulated by interaction with proteins like PDZ domain proteins, chaperones, endocytic adaptors, and cytoskeleton (Bredt and Nicoll, 2003; Malinow and Malenka, 2002; Wenthold et al., 2003).”
PDZ domain proteins of synapses (2004, background): “These PDZ-based interactions are important for the synaptic targeting and regulated trafficking of AMPARs (for recent reviews on this subject, see Ref”
Handbook of ion channels (2015, background): “The glutamate receptors that reside in these synapses are cornerstones of fast signaling in the brain and participate in some forms of activity-dependent plasticity thought to underlie learning and memory (Bredt and Nicoll, 2003; Whitlock et al., 2006).”
Stochastic models of intracellular transport (2013, background): “…of protein trafficking within a neuron provides an important mechanism for modifying the strength of synaptic connections between neurons (Bredt and Nicoll, 2003; Choquet and Triller, 2003; Newpher and Ehlers, 2008; Triller and Choquet, 2005), and synaptic plasticity is generally…”
Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “More recently, TARPs were identified as proteins that serve as auxiliary subunits for AMPAR”
Cascade models of synaptically stored memories. (2005, background): “Furthermore, cascade models provide a framework for understanding and describing the enormous complexity of synaptic plasticity and its molecular underpinnings (Bredt and Nicoll, 2003; Sanes and Lichtman, 1999).”
Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach (2009, positive): “The subunit composition of AMPARs has received a great deal of attention, asit hasbeenproposedtodictate themodeofAMPAR trafficking ( Bredt and Nicoll, 2003; Malinow and Malenka, 2002; Shepherd and Huganir, 2007).”
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses (2008, background): “AMPA receptors are heterotetramers composed of subunits GluR1-4 (Greger et al., 2007), and each of these subunits confers different properties on the receptor (Isaac et al., 2007) and can be regulated differently by interactions with scaffolding and signaling molecules (Bredt and Nicoll, 2003).”
Escape Through a Small Opening: Receptor Trafficking in a Synaptic Membrane (2004, background): “The lifetime of an AMPA receptor is of the order of 24 h, while the lifetime of a synapse is of the order of years, so a regulation mechanism, called the turnover of receptors, is necessary to maintain the number of receptors, and thus to maintain the synaptic weight.(7,8) Corrals can allow receptor”
Time scale of diffusion in molecular and cellular biology (2014, background): “Regulation of the number and type of receptors that contribute to the shaping of the synaptic current is discussed in Bredt and Nicoll (2003), Shi et al (1999), Malinow and Malenka (2002), Choquet and Borgdorff (2002), Triller and Choquet (2003), Holcman and Triller (2006) and Holcman et al (2005a).”
Homeostatic plasticity in the developing nervous system (2004, background): “Once in the membrane, receptors are tethered to synaptic sites through association with multi-protein scaffolding complexes that ultimately link receptors to the cytoskeleto”