Silent synapses and the emergence of a postsynaptic mechanism for LTP

By Geoffrey A. Kerchner, R. Nicoll. Nature Reviews Neuroscience, 2008

609 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/04085a35022ff79fb1c6af5bb06d036c34f26463

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex (2015, background): “Rapid learning could be achieved in our model if instead of growing new synapses, a cell had a multitude of inactive, or “silent” synapses (Kerchner and Nicoll, 2008).”
Mechanisms of CaMKII action in long-term potentiation (2012, methodology): “The CA1 region of the hippocampus, a brain region that is vital for long-term memory formation, has been used as the primary model system for understanding LT”
Learning rules and persistence of dendritic spines (2010, background): “Receptor trafficking assists this ‘functional readout’ of spine structure (Kerchner & Nicoll, 2008; Kasai et al., 2010).”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, methodology): “Finally, slices were transferred through propylene oxide at room temperature and then embedded in LX112 and cured for 48 h at 608C in an oven (Harris et al., 2006).”
The restless engram: consolidations never end. (2012, background): “This Ca signal can activate awide range of signaling pathways including CaMKII, PKC, PKA, and MAPK that have each been implicated in the induction of LTP as well as in its later stabilization (Malenka and Bear, 2004; Huang et al., 2013; Kerchner and Nicoll, 2008; Kessels and Malinow, 2009; Lisman et”
The cerebellar microcircuit as an adaptive filter: experimental and computational evidence (2010, background): “Silent synapses in the cerebellum Silent synapses seem to be a ubiquitous feature of the hippocampus and neocorte”
Super-resolution Imaging of Chemical Synapses in the Brain (2010, neutral): “potentiation during postnatal development (Kerchner and Nicoll, 2008).”
Neuronal Circuit Remodeling in the Contralateral Cortical Hemisphere during Functional Recovery from Cerebral Infarction (2009, background): “Functional change of silent synapses might also contribute to the achievement of new functional circuits after stroke (Kerchner and Nicoll, 2008).”
The molecular and systems biology of memory. (2014, positive): “This Ca signal can activate awide range of signaling pathways including CaMKII, PKC, PKA, and MAPK that have each been implicated in the induction of LTP as well as in its later stabilization (Malenka and Bear, 2004; Huang et al., 2013; Kerchner and Nicoll, 2008; Kessels and Malinow, 2009; Lisman et”