Regenerating the damaged central nervous system

By P. Horner, Fred H. Gage. Nature, 2000

826 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/34af3d57b6e651bd3d469071818e4b75e6c1f372

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Martin E. Schwab
2. G. Martino
3. Zhigang He
4. S. Pluchino
5. Lawrence K Low
6. Hwai-Jong Cheng
7. M. Chao

In Developmental Neuroscience

1. R. Galli
2. Martin E. Schwab
3. G. Martino
4. Angelo Luigi Vescovi
5. Zhigang He
6. S. Pluchino
7. Hwai-Jong Cheng
8. M. Chao

Citations in the corpus

• Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis (2003, background): “They support neurogenesis within restricted areas throughout adulthood, can undergo extensive in vitro expansion and, therefore, have been proposed as a renewable source of neural precursors for regenerative transplantation in various CNS disease”
• Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “Within the brain and spinal cord, tissue injury leads to glial scar formation, which acts as a mechanical barrier and inhibits signal transduction.(59) Glial scar maturation has been shown to be associated with increased fibronectin deposition, which inhibited axonal growth and healing.”
• Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. (2006, background): “Neuronal regeneration through the lesion cavity is only marginally feasible, perhaps due to many obstacles including a severe injury environment filled with deleterious factors and the mechanical barrier caused by the glial scar (2).”
• Axon pruning: an essential step underlying the developmental plasticity of neuronal connections (2006, background): “When axons are injured, the environment that they experience is different from what they have encountered during development (Horner & Gage 2000).”
• Plasticity of motor systems after incomplete spinal cord injury (2001, background): “It is likely that a combination of different experimental manipulations at different time points after injury will be required to induce regeneration and guide regrowing fibres to appropriate targets (see Ref”
• Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth (2002, background): “jpg" NDATA ITEM> ]> The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS”