Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures.

By Penelope C. Georges, W. Miller, D. Meaney, E. Sawyer, P. Janmey. Biophysical Journal, 2006

744 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/3d653d8859d1b35e5e79e7288c5640494f38d943

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

The effect of substrate stiffness on adult neural stem cell behavior. (2009, background): “The stiffness of the matrix has been recently shown to be important to both differentiated and undifferentiated cell types derived from the nervous system [13,16,19,20].”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, background): “human mesenchymal stem cells (14), the migration, adhesion, and cytoarchitecture of smooth muscle cells (15), and the outgrowth of neurons versus glia in mixed cortical cultures (16).”
Matrix elasticity directs stem cell lineage specification. (2006, background): “…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044”
New functions of Müller cells (2013, background): “4, right diagram) (Flanagan et al., 2002; Georges et al., 2006); neuronal growth cones are actively guided by soft substrates and avoid rigid substrates (Franze et al., 2009).”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “, 2006), neurons (Georges et al., 2006), myotubes (Engler et al.”
Substrate modulus directs neural stem cell behavior. (2008, background): “Furthermore, the range of stiffness over which primary neuronal cultures were studied (20,21) was not previously extended below physiological stiffness (,250 Pa), and the extracellular matrix proteins used (generally laminin or fibronectin) present a number of receptor binding motifs that bind numer”
Fibroblast adaptation and stiffness matching to soft elastic substrates. (2007, result): “These variations are almost certainly underestimates because our current studies are limited to substrates stiffer than 1000 Pa, and other studies show that cells can sense differences between substrates softer than 100 Pa (13,28,49).”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “A number of studies demonstrated that matrices characterized by a stiffness similar to that found in the brain drive cultured stem cells into the neurogenic lineage [79].”
Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “A cell is in a physical continuum with its surrounding ECM.”