Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

By Yasuhiko Kawasaki, Zhen-Zhong Xu, Xiaoying Wang, J. Park, Z. Zhuang, P. Tan, Yong‐Jing Gao, Kristine Roy, G. Corfas, Eng H. Lo and 1 more. Nature Medicine, 2008

731 citations recorded by the source corpus.

Subfields: Neurology, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/341c4936d93d0961f5a3b463ec9ba83a23f2d666

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Clifford J. Woolf
2. R. Ji
3. Linda R. Watkins
4. T. Berta
5. Maiken Nedergaard
6. E. Milligan
7. Christian A. von Hehn
8. R. Baron

In Pathology and Forensic Medicine

1. R. Ji
2. Christian A. von Hehn
3. R. Baron
4. Clifford J. Woolf

In Physiology

1. Clifford J. Woolf
2. R. Ji
3. Linda R. Watkins
4. E. Milligan
5. T. Berta
6. Maiken Nedergaard
7. M. Malcangio
8. R. Baron

Citations in the corpus

• Interactions between the immune and nervous systems in pain (2010, background): “Neurotransmitters, neuromodulators and inflammatory mediators are released from primary afferent terminals into the spinal cor”
• Pathological and protective roles of glia in chronic pain (2009, background): “MMP9 -induced pro-IL-1β cleavage leads to p38 MAPK activation in microglia during the onset and early stages of neuropathic pain, whereas MMP2 -induced pro-IL-1β cleavage leads to astrocyte activation during the ongoing and later stages of neuropathic pai”
• Glia and pain: Is chronic pain a gliopathy? (2013, background): “Interestingly, even acute opioid treatment after a subcutaneous injection results in marked SGC reaction in DRGs at 2 hours when morphine analgesia declines [18] (Table 1).”
• Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms (2012, positive): “Following nerve injury, signaling molecules released from primary afferents drive microglial chemotaxis, proliferation and activation (Calvo et al., 2011; Calvo et al., 2010; Kawasaki et al., 2008).”
• MAP kinase and pain (2008, background): “…by enhancing excitatory synaptic transmission, suppressing inhibitory synaptic transmission, and inducing CREB phosphorylation in SCDH neurons (Kawasaki et al., 2008b). p38 also activates phospholipase A2 (PLA2) via activating its downstream kinase MAPKAP-2 (MAPK activated protein kinase-2).”
• Resolvins RvE1 and RvD1Attenuate Inflammatory Pain via Central and Peripheral Actions (2010, methodology): “We delivered synthetic resolvins to the mouse spinal cord via the intrathecal route by lumbar punctur”
• The promises and pitfalls of RNA-interference-based therapeutics (2009, neutral): “However, delivery of siRNAs to the peripheral nervous system by direct infusion into the brain for the relief of chronic pai”