Pathological and protective roles of glia in chronic pain
By E. Milligan, Linda R. Watkins. Nature Reviews Neuroscience, 2009
1,388 citations recorded by the source corpus.
Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes and microglia respond to and release a number of signalling molecules, which have protective and/or pathological functions. Here we review the current understanding of the contribution of glia to pathological pain and neuroprotection, and how the protective, anti-inflammatory actions of glia are being harnessed to develop new drug targets for neuropathic pain control. Given the prevalence of chronic pain and the partial efficacy of current drugs, which exclusively target neuronal mechanisms, new strategies to manipulate neuron–glia interactions in pain processing hold considerable promise.
Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Physiology
View Paper: https://www.semanticscholar.org/paper/2b1b1b7c4d9d5f80906b79aed9be13972bf3b55b
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In Behavioral Neuroscience
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Citations in the corpus
- Glia and pain: Is chronic pain a gliopathy? (2013, background): “Painful syndromes are associated with different glial activation states: (1) glial reaction (ie, upregulation of glial markers such as IBA1 and glial fibrillary acidic protein (GFAP) and/or morphological changes, including hypertrophy, proliferation, and modifications of glial networks); (2)…”
- Astrocytes: biology and pathology (2009, background): “There is a growing body of evidence that astrocytes, which are chronically reactive in the dorsal horn due to local cellular interactions, have the potential to contribute to and exacerbate chronic and neuropathological pain in various ways, including release of neurotransmitters and neuromodulators”