Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
By R. Luthi-Carter, A. Strand, N. L. Peters, S. Solano, Z. Hollingsworth, A. S. Menon, A. Frey, Boris S. Spektor, E. Penney, Gabriele Schilling and 6 more. Human Molecular Genetics, 2000
765 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/339f4aff5f61e1b30c3bf47162d367d0d9dc1bf4
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In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- Regional and cellular gene expression changes in human Huntington's disease brain. (2006, result): “Consistent with previous observations in HD brain and model systems, many of the pathways that show the highest proportion of mRNA changes in caudate relate to neuronal signaling and homeostasis (8).”
- Enriched environments, experience-dependent plasticity and disorders of the nervous system (2006, background): “Synaptic dysfunction in HD mice is associated with transcriptional dysregulation of neurotransmitter receptors and synaptic signal transduction pathway”
- Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice (2003, neutral): “Gene expression profiling has shown that mutant huntingtin protein selectively affects the pattern of gene expression (Luthi-Carter et al., 2000).”
- Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “Gene expression studies in the R6/2 transgenic mouse model of HD also showed reduced expression of metabotropic glutamate receptor mGluR2 that could lead to glutamate-mediated overstimulation of the postsynaptic striatal neurons (103, 104, 357, 359).”