Regional and cellular gene expression changes in human Huntington's disease brain.

By A. Hodges, A. Strand, A. Aragaki, A. Kuhn, T. Sengstag, Gareth P. Hughes, L. Elliston, C. Hartog, D. Goldstein, D. Thu and 13 more. Human Molecular Genetics, 2006

817 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/2ae25dbd5ad0d7387f4dc2764a45375482938cf7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Nathaniel D. Daw
2. John P. O'Doherty
3. Peter S. Dayan
4. Mauricio R. Delgado
5. C. Zuccato
6. E. Cattaneo
7. Okihide Hikosaka
8. M. Valenza

In Molecular Biology

1. Nathaniel D. Daw
2. John P. O'Doherty
3. Okihide Hikosaka
4. Mauricio R. Delgado
5. Bernard W. Balleine
6. M. Valenza
7. E. Cattaneo
8. C. Zuccato

In Neurology

1. Nathaniel D. Daw
2. John P. O'Doherty
3. Bernard W. Balleine
4. Okihide Hikosaka
5. Mauricio R. Delgado

Citations in the corpus

• The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, methodology): “One of the molecular phenotypes in HD patients is transcriptional misregulation in striatum and distinct cortical regions (Hodges et al., 2006).”
• The Role of the Dorsal Striatum in Reward and Decision-Making (2007, background): “…distinct forms of psychopathology, e.g., in Huntington’s, obsessive compulsive disorder, and Tourette’s syndrome on the one hand (Robinson et al., 1995; Bloch et al., 2005; Hodges et al., 2006) and in Parkinson’s and multiple system atrophy on the other (Antonini et al., 2001; Seppi et al., 2006).”
• Multiple Forms of Value Learning and the Function of Dopamine (2009, background): “Furthermore, degeneration of these two corticostriatal circuits has been argued to result in two distinct forms of pathology such as Huntington’s disease, obsessive compulsive disorder and Tourette’s syndrome on the one hand (Robinson et al., 1995; Bloch et al., 2005; Hodges et al., 2006) and Parkin”
• Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, methodology): “Dysfunction at the transcriptional level in HD mainly involves the downregulation of gene expression with the greatest number and magnitude of differentially expressed mRNAs detected in the caudate nucleus, followed by the motor cortex and then the cerebellum (102, 261).”
• Functional organization of the transcriptome in human brain (2008, neutral): “(13) (10) (6) (368) (147) (46) (12) M19”