Protein oxidation and aging

By E. Stadtman. Science, 2006

1,820 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/3342bf86b98e33d2fee6b292ee66113655389d35

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

In Molecular Biology

In Physiology

Citations in the corpus

Antioxidant Activity of Proteins and Peptides (2008, background): “In living tissues, proteins carbonyls increase with oxidative stress and age (Stadtman, 2006).”
Protein carbonylation, cellular dysfunction, and disease progression (2006, background): “Pioneering studies by Stadtman [8, 27] have suggested that the presence of a transition metalbinding site in a protein is a key feature to predict its susceptibility to undergo carbonylation via metal-catalysed oxidation.”
Cytosolic Ascorbate Peroxidase 1 Is a Central Component of the Reactive Oxygen Gene Network of Arabidopsisw⃞ (2005, background): “Protein carbonylation is an irreversible oxidative process leading to a loss of function and often proteolysis of the modified protein (Stadtman, 1992).”
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging (2000, background): “Reactive oxygen species and especially ? O 2 2 are important modulators of NO activity under various pathophysiological conditions (13) and are thought to be involved in the aging process (14).”
Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “Aging and the premature aging diseases Werner syndrome and Hutchinson-Gilford progeria syndrome as well as cancer and other disorders such as Alzheimer’s and Parkinson’s diseases, diabetes, atherosclerosis, caractogenesis, sepsis, cystic fibrosis, psoriasis, rheumatoid arthritis, chronic lung diseas”
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation (2014, methodology): “P A A uthor M anuscript peptide chains (Stadtman, 2006), and this has been observed under CuAAC conditions (Hong et al., 2009b; Kennedy et al., 2011; Kumar et al., 2011).”
Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. (2006, background): “Several studies have demonstrated that the carbonyl content of proteins increases as a function of aging (Smith et al., 1991; Stadtman, 1992).”
Free radicals and antioxidants in human health: current status and future prospects. (2004, background): “…an aggregate of peroxidized lipids and proteins accumulates in lysosomes of aged cells and brain cells of patients with Alzheimer’s disease (Stadtman, 1992).14 Significance of antioxidants in relation to disease Antioxidants may prevent and/or improve different diseased states (Knight,…”
From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health (2007, neutral): “On the contrary, overexpression of Msr activities leads to an increase in resistance to oxidative stress and a significant increase in lifespan (288).”