The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

By Takashi Nagano, Jennifer A. Mitchell, L. Sanz, F. Pauler, Anne Ferguson-Smith, R. Feil, Peter Fraser. Science, 2008

987 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3338cf8982ca5952aa295a57758a436ee97bbb85

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In Cancer Research

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In Genetics

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In Molecular Biology

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7. David P. Bartel
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Citations in the corpus

• Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “However, rather than uniformly localizing to the entire imprinted domain, Airn preferentially accumulates at the Slc22a3 promoter (Nagano et al. 2008).”
• Child health, developmental plasticity, and epigenetic programming. (2011, background): “Also, this histone methyltransferase is recruited to the chromatin by the same ncRNA (120).”
• Linking Long Noncoding RNA Localization and Function. (2016, background): “Air recruits H3K9 histone methyltransferase G9a to maintain the imprinted silencing of multiple genes including the Igf2r locus [14].”
• Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “This phenomenon may be important in gene imprintin”
• No-nonsense functions for long noncoding RNAs. (2011, background): “Other lncRNAs such as Air and Kcnq1ot1 also create repressive environments that may recruit and silence specific cis-linked gene loci by interacting with chromatin and targeting repressive histone modifiers (Nagano et al., 2008; Pandey et al., 2008) (Figure 1A).”
• Genome regulation by long noncoding RNAs (2012, background): “Both Air and Kcnq1ot1 are lncRNAs that are transcribed from the silenced paternal allele, and specifically bind to and recruit the histone H3 lysine 9 methylase G9a in cis to mediate H3K9me3 and transcriptional silencing of Kcnq1 or Igf2r loci, respectively (87, 88).”
• Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Another example of antisense/sense pairing is the action of Airn on the paternal Igf2r cluster (150, 200, 245).”
• Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “Another imprinted lncRNA, antisense Igf2r RNA (AIR), has been shown to be localised to the promoter of a target gene encoding solute carrier family 22 member 3 (SLC22A3) and to direct the histone methyltransferase G9a to this locus [81].”
• Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene (2010, background): “A recent study utilized high-magnification RNA–DNA FISH assay to demonstrate that large ncRNA, Air, interacts with the chromatin of cis-linked target gene promoter and recruits the H3K9 histone methyltransferase to repress the gene expression (Nagano et al., 2008).”