No-nonsense functions for long noncoding RNAs.

By Takashi Nagano, Peter Fraser. Cell, 2011

892 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc2fc77577ebab0f62e580e9dbec84b9e78da0c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Howard Y. Chang
2. Yvonne Tay
3. Johannes Rinn
4. P. Pandolfi
5. M. Gorospe
6. I. Bozzoni
7. A. Lal
8. K. Prasanth

In Molecular Biology

1. Howard Y. Chang
2. Yvonne Tay
3. P. Pandolfi
4. Johannes Rinn
5. M. Gorospe
6. I. Bozzoni
7. L. Salmena
8. A. Lal

Citations in the corpus

• A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA (2011, positive): “Many new functions have been assigned to noncoding RNAs both in the nucleus and in the cytoplasm (Mattick, 2011; Nagano and Fraser, 2011).”
• The multilayered complexity of ceRNA crosstalk and competition (2014, methodology): “A combined computational and experimental approach has been used to identify CNOT6L and VAPA as protein-coding transcripts that regulate PTEN transcript and protein expression in a Dicer-dependent manner, antagonize downstream PI(3)K signalling and possess growthand tumour-suppressive properties(17)”
• A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? (2011, background): “Although recent studies have begun associating a subset of long noncoding RNAs (lncRNAs) with specific regulatory mechanisms, less is known about noncoding transcripts on a genome-wide scale (Nagano and Fraser, 2011).”
• Genome regulation by long noncoding RNAs (2012, background): “Biochemical experiments were able to characterize many abundant structural and regulatory RNAs by cellular localization and sequence similarity (5, 8–12), and genetic studies identified a few lncRNA genes involved in imprinting and other cellular processes (XIST, H19, AIR) (13, 14).”
• Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “Similarly, the imprinted Air lncRNA interacts with the histone-methyl transferase G9a and recruits it to epigenetically silence Slc22a3 [18] [19] [20].”