Toll‐like Receptor and RIG‐1‐like Receptor Signaling

By Taro Kawai, Shizuo Akira. Annals of the New York Academy of Sciences, 2008

959 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/332b00821d4155976c01dc0c9650cf2f13e083ee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Shizuo Akira
2. Taro Kawai
3. S. Lehnardt
4. Jüergen Cox
5. J. Tschopp
6. Matthias Mann
7. S. Ghosh
8. Luke A. O'Neill

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. S. Lehnardt
4. J. Tschopp
5. Aubry Tardivel
6. Greta Guarda
7. R. Medzhitov
8. O. Takeuchi

Citations in the corpus

• Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “…(PRRs) that differ fundamentally with respect to their cellular localization to detect viruses: the transmembrane-localized Toll-like receptors (TLRs) and the cytosolic retinoic acidinducible gene-I (RIG-I) andmelanomadifferentiation-associated gene 5 (MDA5) receptors (Kawai and Akira, 2008).”
• RIG-I dependent sensing of poly(dA-dT) via the induction of an RNA polymerase III transcribed RNA intermediate (2009, neutral): “The innate immune system is the first line of defens”
• Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “To date, at least 13 TLRs have been identified in mammals, which trigger innate and modify adaptive immune responses (Kawai and Akira, 2008).”
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “In addition to recognizing poly(I:C), TLR3 recognizes the genomic RNA of reoviruses, dsRNA produced during the replication of single-stranded RNA (ssRNA), viruses, including respiratory syncytial virus, encephalomyocarditis virus and West Nile virus, and certain small interfering RNA”
• Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “RIG-I and MDA5 recruit adaptor molecules like Mavs (also called Cardif, VISA, or IPS-1) (Meylan et al., 2005) that are distinct from those that mediate TLR signaling, although both pathways converge on IFN regulatory factors (IRFs) and NF-kB for the production of inflammatory cytokines and IFNs (Kaw”