Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

By Rachel I. Wilson, R. Nicoll. Nature, 2001

1,634 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3311a659e609ed3ff2097d218284d54575f91537

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Pertwee
2. K. Mackie
3. V. Di Marzo
4. George Kunos
5. E. Rancz
6. Tamás F. Freund
7. I. Katona
8. P. Castillo

In Cognitive Neuroscience

1. R. Pertwee
2. K. Mackie
3. E. Rancz
4. V. Di Marzo
5. P. Castillo
6. L. Iversen
7. David P. Finn
8. Tamás F. Freund

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. K. Mackie
4. George Kunos
5. Tamás F. Freund
6. P. Pacher
7. S. Batkai
8. R. Mechoulam

Citations in the corpus

• Cannabinoid physiology and pharmacology: 30 years of progress. (2004, background): “…in understanding how endocannabinoids produce functional changes in the CNS has come from the recent work of Wilson and Nicoll (Wilson et al., 2001; Wilson and Nicoll, 2001) linking cannabinoid receptors to a phenomena previously well characterized by Alger and colleagues (Alger et al., 1996;…”
• Endocannabinoid signaling and synaptic function (2012, background): “Consistently, DSI and eCB-mediated iLTD were augmented in these mice (Massa et al., 2010).”
• Cannabis and the brain. (2003, methodology): “The physiological importance of cannabinoid-mediated DSI may be to decrease GABAergic inhibition of these cells and thus facilitate learning when hippocampal inputs are active (Wilson and Nicoll, 2001).”
• Stress-induced analgesia. (2009, background): “retrograde signalling has been observed or hypothesized to occur in stress-responsive brain regions including the hippocampus, amygdala, and in nociceptive regions such as the PAG, RVM, spinal trigeminal nucleus, and regions of the spinal cord (Jennings et al., 2001; Katona et al., 2001; Lichtman et”
• Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission (2001, background): “CB1 cannabinoid receptors at the synaptic level in the amygdala The significance of the localization and function of CB1 receptors at the synaptic level has been emphasized by recent discoveries in the hippocampus and cerebellum, suggesting that endocannabinoids may act as retrograde synaptic messen”
• Metaplasticity: tuning synapses and networks for plasticity (2008, background): “These receptors are activated by endogenous endocannabinoids that serve as retrograde signals following postsynaptic group-1 mGluR activation and membrane depolarizatio”
• International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors (2002, background): “…and both analogs share the ability of SR141716A to attenuate responses to established cannabinoid receptor agonists (Gifford et al., 1997b; Al-Hayani and Davies, 2000; Cosenza et al., 2000; Izzo et al., 2000; Huang et al., 2001; Maejima et al., 2001; Simoneau et al., 2001; Wilson and Nicoll, 2001).”
• Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism (2003, background): “Endocannabinoids have been shown to act as retrograde messengers that reduce synaptic glutamate and GABA release (Shen et al., 1996; Auclair et al., 2000; Wilson and Nicoll, 2001; Wilson et al., 2001).”
• Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function (2009, background): “Anandamine, then, functions as a retrograde messenger and regulates synaptic transmission by interacting with specific receptors in the presynaptic neurons/terminals (498).”
• The endogenous cannabinoid system controls extinction of aversive memories (2002, background): “As several recent studies indicate an involvement of CB1 in GABA-mediated synaptic transmission in hippocampu”