Stress-induced analgesia.

By R. K. Butler, David P. Finn. Progress in neurobiology, 2009

675 citations recorded by the source corpus.

For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, gamma-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.

Subfields: Cellular and Molecular Neuroscience, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/1016667b291049e462e1ae8bd2326fe16b45d034

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Katja Wiech
2. Irene Tracey
3. Joseph C. Franklin
4. J. Hooley

In Pharmacology

1. Katja Wiech
2. Irene Tracey

In Physiology

1. Katja Wiech
2. Irene Tracey

Citations in the corpus

• Don't fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear (2017, neutral): “On the other hand, the pain-threshold s sensitive to a large number of factors such as hormonal variaions (Riley et al., 1999), stress (Butler and Finn, 2009), or fear and nxiety (Rhudy and Meagher, 2000).”
• Why Do People Hurt Themselves? A New Conceptual Model of Nonsuicidal Self-Injury (2018, background): “In other words, pain perception during NSSI may be altered by the effects of pain offset (see Grill & Coghill, 2002), expectations of little pain (see Price et al., 1999), or increased stress (see Butler & Finn, 2009).”
• The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, positive): “In this view, high threat might elicit intense negative affect, high arousal, and reduced pain sensitivity — a phenomenon often referred to as stress-induced analgesia (Flor and Grusser, 1999; Martenson et al., 2009; for review see Ford and Finn, 2008 and Butler and Finn, 2009).”