Endocannabinoid signaling and synaptic function
By P. Castillo, Thomas J. Younts, A. Chávez, Y. Hashimotodani. Neuron, 2012
995 citations recorded by the source corpus.
Endocannabinoids are key modulators of synaptic function. By activating cannabinoid receptors expressed in the central nervous system, these lipid messengers can regulate several neural functions and behaviors. As experimental tools advance, the repertoire of known endocannabinoid-mediated effects at the synapse, and their underlying mechanism, continues to expand. Retrograde signaling is the principal mode by which endocannabinoids mediate short- and long-term forms of plasticity at both excitatory and inhibitory synapses. However, growing evidence suggests that endocannabinoids can also signal in a non-retrograde manner. In addition to mediating synaptic plasticity, the endocannabinoid system is itself subject to plastic changes. Multiple points of interaction with other neuromodulatory and signaling systems have now been identified. Synaptic endocannabinoid signaling is thus mechanistically more complex and diverse than originally thought. In this review, we focus on new advances in endocannabinoid signaling and highlight their role as potent regulators of synaptic function in the mammalian brain.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology
View Paper: https://www.semanticscholar.org/paper/028bae66694a9407dd07bd6f941116c9e8230773
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
In Pharmacology
Citations in the corpus
- Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “Abbreviations THC ∆9-tetrahydrocannabinol CBR Cannabinoid receptor AEA N-arachidonoyl-ethanolamine 2-AG 2-arachidonoylglycerol CBD Cannabidiol GPCR G protein-coupled receptor TRPV1 Transient receptor potential cation channel subfamily V member 1 NAPE N-acyl-phosphatidylethanolamine NAPE-PLD NAPE-spe”
- Cannabidiol as a Potential Treatment for Anxiety Disorders (2015, background): “The eCB system is also integral to regulation of emotional behavior, being essential to forms of synaptic plasticity that determine learning and response to emotionally salient, particularly highly aversive events [29, 30].”
- An introduction to the endogenous cannabinoid system (2015, background): “A great deal of work in subsequent years has investigated mechanisms and extended these results to many other neurons and brain regions, suggesting endocannabinoids (likely, 2-AG) are a major contributor to short term synaptic plasticity reviewed by (89, 96, 97).”