Transcription and processing of human microRNA precursors.

By Bryan R. Cullen. Molecules and Cells, 2004

810 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/32bfcb5753a365111249e772d5eb6a66fa18cf2d

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Citations in the corpus

Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth (2008, background): “Interestingly, we found that some copies of the cloned miR-21 and miR-205 had heterogenous 39 ends, with an extra C nucleotide on the 39 end of 68% of the miR-21 copies and an extra U on the 39 end of 33% of the miR-205 copies, presumably derived from wobble digestion of the pre-miRNAs by Dicer (Fig”
microPrimer: the biogenesis and function of microRNA (2005, background): “…least eight animal miRNA, miR-127, miR-136, miR-196, miR-431, miR-433-3p, miR433-5p, miR-434-3p and miR-434-5, and two viral miRNAs, miR-BART2 and SVmiRNA, also act to cleave their targets (Mansfield et al., 2004; Pfeffer et al., 2004; Yekta et al., 2004; Davis et al., 2005; Sullivan et al., 2005).”
Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, neutral): “…(i) the siRNA is loaded onto an enzyme complex that interferes with the transcription or translation of mRNAs with a homologous se- quence (Cullen 2004; Meister and Tuschl 2004); (ii) the siRNA is loaded onto an enzyme complex that targets chromatin regions with DNA that is homologous…”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Recent genomic analysis indicates that primary miRNA precursors are long polycistronic transcripts that are similar to mRNA in that they have distinct 5’ and 3’ boundaries, 7-methyl guanylate (m7G) caps and poly(A) tails [12, 38-41].”
The imprinted H19 noncoding RNA is a primary microRNA precursor. (2007, background): “Instead, miRNA hairpins are generally located in introns or in the exons of noncoding RNAs (Cullen 2004).”
Combinatorial microRNA target predictions (2005, background): “dtd" [ ]> MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3′ untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcrip”
Clustering and conservation patterns of human microRNAs (2005, methodology): “The ‘same-strand’ approach that was performed throughout this study was chosen since same-strand miRNA clustering might imply that they are transcribed together [(1,9,12,14–18) and reviewed in ( 2 ,5)].”
MicroRNA biogenesis: coordinated cropping and dicing (2005, background): “jpg" NDATA ITEM> ]> MicroRNAs (miRNAs) are single-stranded RNAs (ssRNAs) of 19–25 nucleotides in length that are generated from endogenous hairpin-shaped transcript”