The imprinted H19 noncoding RNA is a primary microRNA precursor.
By Xuezhong Cai, Bryan R. Cullen. RNA: A publication of the RNA Society, 2007
640 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/add5139b16ac4f8960fe8fcb8b3aeddd2e9b5166
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In Cancer Research
- Iain M. Dykes
- Chris P. Ponting
- Jeannie T. Lee
- P. Oliver
- Wolf Reik
- Costanza Emanueli
- Howard Y. Chang
- Igor Ulitsky
In Molecular Biology
- Iain M. Dykes
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- Wolf Reik
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Citations in the corpus
- Evolution and functions of long noncoding RNAs. (2009, background): “Recently, it was found that the H19 RNA is host to an exonic microRNA, miR-675, which, as a result, is also imprinted and maternally expressed (Cai and Cullen, 2007).”
- Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels (2019, background): “first discovered in 2007 that the non-coding RNA H19 produces a 23 nt miRNA precursor of miRNA675 that suppresses translation of insulin growth factor receptor (Igf1r), thereby inhibiting cell proliferation in response to cellular stress or oncogenic signals [87,88].”
- Long Noncoding RNAs: Past, Present, and Future (2013, background): “H19 is host to miR-675 (Cai and Cullen 2007; Keniry et al. 2012); Gas5 gives rise to 10 highly conserved snoRNAs (Smith and Steitz 1998); and the imprinted Gtl2, antiRtl1, and Mirg RNAs are hosts to almost 50 miRNAs and 40 snoRNAs (da Rocha et al. 2008).”
- Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “One of the first lncRNAs to be discovered and perhaps the most studied, H19, contains miR-675 embedded within its first intron [39].”
- Long Non-coding RNAs in the Cytoplasm (2016, background): “In this regard, H19 has a prodifferentiation function in primary myoblasts and regenerating skeletal muscles due to the resulting miR-675-3p and miR-6755p [86,87].”
- The H19 Non-Coding RNA Is Essential for Human Tumor Growth (2007, background): “A recent report suggested that H19 is a precursor for microRNA 675 [78].”