Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

By R. de la Fuente-Fernández, T. Ruth, V. Sossi, M. Schulzer, D. Calne, A. Stoessl. Science, 2001

992 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/32b079597e5613c942e800700c8c1adee81690fe

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

RESILIENCE TRAINING THAT CAN CHANGE THE BRAIN (2018, neutral): “…pain (Kam-Hansen et al., 2014; Kaptchuk et al., 2008; Vase, Riley, & Price, 2002) or asthma, (Kemeny et al., 2007; Luparello, Lyons, Bleecker, & McFadden, 1968), or even seemingly pure neurological diseases such as Parkinson’s disease (De la Fuente-Fernández et al., 2001; Lidstone et al., 2010).”
Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture (2005, background): “The reward expectation process involving the rACC is reported to be mediated by dopaminergic nigro-striatal system (Fuente-Fernandez et al., 2001; O’Doherty et al., 2002a; Schultz, 2002).”
Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses (2003, background): “…in placebo analgesia (Amanzio and Benedetti, 1999; Benedetti et al., 1999b) and of endogenous dopamine in the placebo response of Parkinsonian patients (de la Fuente-Fernandez et al., 2001) are believed to involve both conditioning and cognitive factors (Price and Fields, 1997; Price, 2002).”
Neurobiological Mechanisms of the Placebo Effect (2005, background): “A recent study used positron emission tomography (PET) to assess the competition between endogenous dopamine and [ 11 C]raclopride for D 2 /D 3 receptors, a method that allows identification of endogenous dopamine release (de la Fuente-Fernandez et al., 2001).”
Placebo Effects: Biological, Clinical and Ethical Advances (2010, positive): “This paradigm demonstrates that such verbal cues can manipulate expectations and mediate placebo effects, including placebo analgesic effects in experimental (21) and clinical pain (22); and placebo induced changes in motor performance in Parkinson's Disease (23,24) and changes in emotions (25) and ”
The Placebo Effect in Alternative Medicine: Can the Performance of a Healing Ritual Have Clinical Significance? (2002, background): “Patients with Parkinson disease seem to have a robust placebo response (114, 115); the biochemical substrate of this response in relation to the release of dopamine in the striatum has recently been shown on positron emission tomography (116).”
The neural correlates of placebo effects: a disruption account (2004, background): “…outcome of placebo effects—identifying changes in the brain regions that most directly relate to subjective changes in symptoms, and comparing these changes with those stemming from active pharmacological agents (de la Fuente-Fernandez et al., 2001; Leuchter et al., 2002; Mayberg et al., 2002).”
A common neurobiology for pain and pleasure (2008, background): “In addition, considerable evidence suggests that expectation of treatment effect, which contributes to placebo analgesia, is a type of reward expectatio”
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. (2008, background): “There is an emerging literature examining the neurobiologic features of placebo effects across a variety of domains such as mood and affective regulation(5,6) and motor control in Parkinson disease.(7,8) However, most studies in this area have used pain models in the assessment of placebo-induced an”
Habits, rituals, and the evaluative brain. (2008, background): “…striatum (from Aosaki et al. 1994b) Spike rasters (below) and histograms of those spikes (above) are aligned (vertical lines) at touch of the food reward (a) and at the conditional stimulus click sound indicating reward. elicit dopamine release in the striatum (de la Fuente-Fernandez et al. 2001).”
Individual Differences in Marketing Placebo Effects: Evidence from Brain Imaging and Behavioral Experiments (2015, background): “In their study, De la Fuente-Fernández et al. (2001) even showed the power of placebo effects by providing in vivo evidence for the substantial release of endogenous dopamine in the striatum of Parkinson’s disease”