Neurobiological Mechanisms of the Placebo Effect

By F. Benedetti, Helen S. Mayberg, Tor D. Wager, C. Stohler, Jon-Kar Zubieta. Journal of Neuroscience, 2005

757 citations recorded by the source corpus.

Any medical treatment is surrounded by a psychosocial context that affects the therapeutic outcome. If we want to study this psychosocial context, we need to eliminate the specific action of a therapy and to simulate a context that is similar in all respects to that of a real treatment. To do this,

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/06f8b5b036af04e6e60ec702ad9c057bba980e40

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Citations in the corpus

Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). (2014, neutral): “In particular, the placebo analgesic response appears to result from a balance between endogenous opioid and cholecysto- 2156 J.-P. Lefaucheur et al. / Clinical Neurophysiology 125 (2014) 2150–2206 kinin secretion (Benedetti et al., 2005).”
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome (2008, background): “Additionally in terms of limitations, it is unclear whether our placebo outcomes correspond to biological changes in irritable bowel syndrome or have any of the biochemical, neuroendocrine, or neuroanatomical correlates of placebo response found in recent laboratory experiments”
The cerebral signature for pain perception and its modulation. (2007, background): “Much of our knowledge of the placebo effect has come from early animal studies based upon Pavlovian conditioning and expectancy (Benedetti et al., 2005; Haour, 2005).”
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. (2008, background): “However, this interpretation has now been challenged by increasing evidence that these effects are mediated by specific neural mechanisms.(4) Clarifying these mechanisms would aid in the development of strategies to reduce response variability in clinical trials, with considerable implications for n”
Physiology and neurobiology of stress and adaptation: central role of the brain. (2007, background): “When considering pain and brain activation associated with pain, it is important to recognize the role of brain mechanisms in the placebo effect, in which perceptions of pain can be manipulated by expectations (28, 365).”
A common neurobiology for pain and pleasure (2008, background): “Interestingly, when subjects who were not expecting an injection of pain-relieving morphine received a hidden injection, its analgesic effects were significantly reduce”
A comprehensive review of the placebo effect: recent advances and current thought. (2008, background): “Researchers who study the placebo effect are examining the psychosocial context surrounding the patient and the effect that this context has on the patient's experience, brain, and body (Colloca & Benedetti 2005).”
Neuromarketing: the hope and hype of neuroimaging in business (2010, background): “The neural correlates of the analgesic placebo effect are widespread but generally point to a modulation of the cortical pain matrix in the brai”
Activation of the opioidergic descending pain control system underlies placebo analgesia. (2009, background): “…effects are ubiquitous in modern medicine, not only as a control in randomized controlled trials but also as a subject of intense study in diverse clinical fields, such as Parkinson’s disease, depression, immune function, and pain (Benedetti et al., 2005; Enck et al., 2008; Price et al., 2008).”
Functional grouping and cortical-subcortical interactions in emotion: A meta-analysis of neuroimaging studies (2008, neutral): “In support of this notion, emotion- and pain-related activity in IFG and the operculum is modified by manipulations of the context in which affective stimuli are presented, such as when pain expectations are changed (Benedetti et al., 2005; Kong et al., 2006; Wager et al., 2004b).”