A common neurobiology for pain and pleasure

By S. Leknes, Irene Tracey. Nature Reviews Neuroscience, 2008

758 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/5c7a6d152be4a14216e5ff7dcd87fefc35df55fe

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Citations in the corpus

Valence and Value (2018, neutral): “…involving not just subcortical evaluative regions in the basal ganglia, but also the anterior insula and anterior cingulate, together especially with orbitofrontal and ventromedial prefrontal cortex (Leknes & Tracey, 2008; FitzGerald et al., 2009; Plassmann et al., 2010; Bartra et al., 2013).”
An integrative and functional framework for the study of animal emotion and mood (2010, background): “…opioidergic) appear to be prime candidates for the latter reward/punishment systems (Gray 1994; Burgdorf & Panksepp 2006; Berridge 2007; Leknes & Tracey 2008), and it is possible that they, and higher cortical areas (e.g. anterior cingulate cortex, orbitofrontal cortex), somehow…”
Dissecting components of reward: ‘liking’, ‘wanting’, and learning (2009, neutral): “[4 ,5,6,7 ,8,9 ,10 ,11–13].”
Cognitive bias as an indicator of animal emotion and welfare: Emerging evidence and underlying mechanisms (2009, background): “This system may thus provide a common currency for valuation of both positive and negative outcomes (Leknes and Tracey, 2008).”
The Brain Basis of Positive and Negative Affect: Evidence from a Meta-Analysis of the Human Neuroimaging Literature. (2016, background): “These findings might suggest that it is not neurons, but neurochemicals, that are valence specific, but research shows that neurochemicals such as opiods and dopamine are general to both pleasure and pain in mammals (Leknes and Tracey 2008).”
Descending pain modulation and chronification of pain (2014, neutral): “The somatosensory cortices (S1 and S2) and the insula are believed to encode the sensory features of pain, which include quality (stinging, burning or aching), location and duration [37,38 ■ ,39].”
Synchrony as an Adaptive Mechanism for Large-Scale Human Social Bonding (2016, neutral): “The EOS is central in opioid-mediated reward (Koob 1992; Olmstead & Franklin 1997; Comings et al. 1999), social motivation (Chelnokova et al. 2014), and pleasure and pain perception (Janal et al. 1984; Leknes & Tracey 2008), and is associated with feelings of euphoria (Boecker et al. 2008).”
The influence of negative emotions on pain: Behavioral effects and neural mechanisms (2009, neutral): “A deeper understanding of their neural basis could not only broaden our view on pain, but also open new approaches to treatment of acute and chronic pain states (Leknes and Tracey, 2008).”
Joy and Calm: How an Evolutionary Functional Model of Affect Regulation Informs Positive Emotions in Nature (2016, background): “Finally, opioids are well-established in the relief of pain, with research suggesting that both opioid and dopamine systems are important in modulating both pain and pleasure (Leknes and Tracey 2008).”
The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. (2009, background): “These aversive processes are believed to interact with appetitive motivational systems, though mechanisms of such interactions are poorly understood (Konorski, 1967; Dickinson and Dearing, 1979; Daw et al., 2002; Fields, 2007; Koob and LeMoal, 2008; Leknes and Tracey, 2008).”
Emotion and the motivational brain (2009, background): “…increase in NAc during picture processing contrasts with some studies suggesting that increased NAc activity is driven by stimulus salience (cues of significance, whether pleasant or unpleasant), rather than selectively by positive hedonic cues (see review by Leknes and Tracey, 2008).”