IKKε and TBK1 are essential components of the IRF3 signaling pathway

By Katherine A. Fitzgerald, S. McWhirter, K. Faia, D. C. Rowe, E. Latz, D. Golenbock, A. Coyle, S. Liao, T. Maniatis. Nature Immunology, 2003

1,918 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/f445a2423724591cf2a79ae3ff89eb30723ac3fa

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In Cancer Research

1. Shizuo Akira
2. Taro Kawai
3. K. Takeda
4. Satoshi Uematsu
5. S. Ghosh
6. M. Karin
7. O. Takeuchi
8. T. Kaisho

In Immunology

1. Shizuo Akira
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6. Zhijian J. Chen
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8. K. Takeda

Citations in the corpus

• Interferons at age 50: past, current and future impact on biomedicine (2007, background): “The IKK protein kinase complex phosphorylates IκB and releases it from NFκB; NFκB is then further activated by phosphorylation by other kinase”
• Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I (2005, methodology): “Its activation occurs through redundant actions of TBK1 or IKKe protein kinases, which catalyze its carboxyl-terminal phosphorylation and result in nuclear translocation, DNA binding, and transcription-effector actions ( 6 , 23).”
• Evasion of Type I Interferon by SARS-CoV-2 (2020, background): “The phosphorylated IRF3 forms a dimer and translocates to the nucleus, activating the transcription of type I IFN (IFN-I) genes (Fitzgerald et al., 2003; Liu et al., 2015).”
• Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 (2005, background): “IRF-3 is phosphorylated at specific serine residues (5, 6) by two members of the I B kinase (IKK) family, TANK-binding kinase 1 (TBK1) and IKKi/IKK (7, 8), and forms an active DNA-binding holocomplex with a transcriptional coactivator, p300 or the CREBbinding protein, in the nucleus (9).”
• Galectin-8 targets damaged vesicles for autophagy to defend cells against bacterial invasion (2012, neutral): “; siGAL8 #36 5′-CCCACGCCUGAAUAUUAAAGCAUUU; siGAL8 #38 5′-GGACAAAUUCCAGGUGGCUGUAAAU; siGAL3 #669 5′-AAGCCCAAUGCAAACAGAAUUGCUU; siGAL3 #670 5′-GAGAACAACAGGAGAGUCAUUGUUU; siGAL9 #807 5′-GGCUUCAGUGGAAAUGACAUUGCCU; siGAL9 #809 5′-UGUGCAACACGAGGCAGAACGGAGG; siTBK1 5′-GACAGAAGUUGUGAUCACA(TT”
• Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 (2005, positive): “The kinases that phosphorylate IRF3 have recently been identified as the IKK-like kinases TBK1 and IKK (Fitzgerald et al., 2003; Sharma et al., 2003).”