Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

By J. Fontenot, J. P. Rasmussen, L. Williams, James L. Dooley, A. Farr, Alexander Y. Rudensky. Immunity, 2005

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Citations in the corpus

Foxp3 instability leads to the generation of pathogenic memory T cells in vivo (2009, positive): “In addition, peripheral T reg cells, particularly the CD4 + CD25 − Foxp3 + subset, are unstable in a lymphopenic setting, and those unstable T reg cells can convert to follicular helper T cells and promote the formation of germinal centers in mouse Peyer's patche”
Journey through the thymus: stromal guides for T-cell development and selection (2006, background): “In addition to the deletional mechanism that ensures self-tolerance, it is also important to note that the medulla is thought to be the place for the production of regulatory T cell”
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation (2007, methodology): “KI mice in order to reliably monitor T-reg in vivo based on the linked expression of green fluorescent protein (GFP) in Foxp3 + T cell”
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells (2009, background): “Further analysis of the T reg cell phenotype assessing expression of the T reg cell–specific transcription factor Foxp3 (ref”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “…with contributing a distinct genetic sig- nature to T reg cells, Foxp3 conveys regulatory activity to nT reg cells, iT reg cells, and, upon ectopic expression, in con- ventional T cells (Schubert et al., 2001; Fontenot et al. 2003, 2005; Hori et al., 2003; Gavin et al., 2007; Hill et al., 2007).”
Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, methodology): “To directly determine the role of IL-1 in the induction of IL-17 in Foxp3+ T cells, we utilized Foxp3-GFP reporter mice (Fontenot et al., 2005).”