Function of Mitochondrial Stat3 in Cellular Respiration

By J. Węgrzyn, Ramesh Potla, Y. Chwae, N. B. Sepuri, Qifang Zhang, T. Koeck, Marta Derecka, Karol Szczepanek, M. Szeląg, A. Górnicka and 16 more. Science, 2009

1,019 citations recorded by the source corpus.

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3–/– cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/324c68d215f63b194523548c84eead7a9e3d3aef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

In Oncology

Citations in the corpus

JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. (2012, background): “Beyond their role as transcription factors, a direct role of STATs in mitochondrial function makes the argument for key roles in metabolism even more compelling (Gough et al., 2009; Potla et al., 2006; Wegrzyn et al., 2009).”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Recent findings indicate that mitochondrial STAT3 sustains the altered glycolytic and OXPHOS activities characteristic of cancer cells (210).”
Metabolic Instruction of Immunity (2017, positive): “Coincidentally, STAT3 was found to localize to mitochondria and interact with ETC complexes, which helped maintain efficient OXPHOS in the heart (Wegrzyn et al., 2009).”
STAT3 signaling in immunity (2016, background): “In 2009, the intriguing discovery was made that STAT3 associates with mitochondria and therein regulates electron transport chain function as well as glycolytic and oxidative phosphorylation [13, 48].”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, positive): “Intriguingly, STAT3 has been shown to directly regulate the activities of the mitochondrial electron transport chain in liver and heart, which could provide a connection between effects of IL-6 signaling and fatty acid oxidation in skeletal muscle (Wegrzyn et al., 2009).”