Characterization of CNS precursor subtypes and radial glia.

By Eva Hartfuss, R. Galli, N. Heins, M. Götz. Developmental Biology, 2001

789 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/323f81bf820f3f0f3ee14158ac79b78c8069448a

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Citations in the corpus

Glial cells generate neurons: the role of the transcription factor Pax6 (2002, background): “First, Pax6 is localized in cells with radial glial properties such as RC2 and GLAST immunoreactivity and hGFAP–GFP expressio”
Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia (2002, methodology): “Several recent reports have raised doubts about the distinction between radial glial and precursor cells by demonstrating that radial glial cells are themselves neuronal progenitor cells (Malatesta et al., 2000; Hartfuss et al., 2001; Miyata et al., 2001; Noctor et al., 2001).”
The role of notch in promoting glial and neural stem cell fates. (2002, background): “Several recent reports have found that radial glia may be multipotent neural progenitors in the embryo (Hartfuss et al. 2001, Malatesta et al. 2000, Noctor et al. 2001).”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “It has been reported that cells expressing radial glia markers persist in neurospheres [44] and that neurospheres can ‘‘differentiate’’ into radial glia [57].”
Development of the human cerebral cortex: Boulder Committee revisited (2008, background): “Radial glia share some molecular characteristics with earlier neuroepithelial cells, including the expression of nestin and antigens that are recognized by the RC1 and RC2 antibodie”
Neural progenitors, neurogenesis and the evolution of the neocortex (2014, background): “…one of the daughter cells becomes either an NEC or an apical radial glia (i.e. the NPC type that NECs transform into at the onset of neurogenesis) (Hartfuss et al., 2001; Kriegstein and Götz, 2003; Götz and Huttner, 2005); and (2) the generation of a lineage-wise downstream cell type, as the…”
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases (2004, background): “Most, if not all, cortical progenitor cells in the VZ are radial glial cell”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “They are comprised mainly of radial glia, progenitors with cell bodies close to the ventricles and a long radial process that contacts the pial surface of the brain (Hartfuss et al., 2001; Merkle et al., 2004).”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “While RGCs also express these proteins, they are distinguished from neuroepithelial cells by the presence of glial markers including astrocyte-specific glutamate transporter (GLAST) and brain lipid binding protein (BLBP) (Hartfuss et al., 2001; Kriegstein and Gotz, 2003).”
Modes of neuronal migration in the developing cerebral cortex (2002, background): “In addition, it seems that radial glia give rise to a second population of postmitotic neurons, which typically corresponds to the locomoting population that relies on glial guidanc”
Adult neurogenesis and neural stem cells of the central nervous system in mammals (2002, background): “Other studies from the developing cortex demonstrated that radial glial cells generate neurons and glial cells (Hartfuss et al., 2001; Miyata et al., 2001).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, methodology): “When the promoter for BLBP, a protein expressed by RG cells throughout the developing brain and spinal cord (Feng et al. 1994, Kurtz et al. 1994, Hartfuss et al. 2001), was used to drive Cre-recombinase gene expression in a Cre/loxP fate mapping experiment, large numbers of neurons in virtually all…”
Developmental cell biology: The cell biology of neurogenesis (2005, background): “The neuroepithelial properties that are maintained by radial glial cells include: the expression of neuroepithelial markers such as the intermediate-filament protein nesti”
Development and Evolution of the Human Neocortex (2011, positive): “Further studies showed that, in the rodent, the vast majority of progenitor cells in the VZ have RG morphology and contact both the ventricular (apical) and pial (basal) surfaces of the neocortex (Hartfuss et al., 2001; Noctor et al., 2002).”
Radial glia serve as neuronal progenitors in all regions of the central nervous system. (2004, background): “Thorough analysis of transgenic mice expressing found to be contained in a subpopulation of dissociated radial glia (Hartfuss et al., 2001).”