Tumour biology: Senescence in premalignant tumours

By M. Collado, Jesús Gil, A. Efeyan, C. Guerra, A. J. Schuhmacher, M. Barradas, Alberto Benguría, Á. Zaballos, J. Flores, M. Barbacid and 2 more. Nature, 2005

1,538 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/321f4e3dd45aba9e0859c02919df83b4bbc470b7

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Citations in the corpus

Therapy-induced senescence in cancer. (2010, background): “Finally, the proteins Dec1 (BHLHB2) and DcR1 (TNFRSF10D) have been associated with senescence in noncancer tissues (15).”
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. (2006, background): “The senescent phenotype was recently shown to play a role in the protection from tumor development in vivo (Braig et al., 2005; Chen et al., 2005; Collado et al., 2005; Michaloglou et al., 2005).”
Cellular Senescence: Defining a Path Forward. (2019, positive): “OIS or senescence induced by loss of a tumor suppressor was veriﬁed in vivo in human and murine preneoplastic lesions (Collado et al., 2005; Gorgoulis and Halazonetis, 2010; Kuilman and Peeper, 2009) and primary or treated neoplasias (Haugstetter et al., 2010).”
Accumulation of senescent cells in mitotic tissue of aging primates. (2007, background): “Some of these heterochromatin proteins are also elevated in premalignant lesions where they are thought to contribute to a stable cellular growth arrest to prevent the outgrowth of these lesions into malignant tumors (Collado et al., 2005; Michaloglou et al., 2005).”