Therapy-induced senescence in cancer.

By J. Ewald, Joshua A. Desotelle, G. Wilding, D. Jarrard. Journal of the National Cancer Institute, 2010

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Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Although TIS can be initially beneficial in blocking tumor cell proliferation, it also impairs the elimination of senescence tumor cells from the immune system.”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “In particular, this failsafe cellular senescence reportedly occurs in response to (1) potentially carcinogenic events including oncogene activation or oncosuppressor gene inactivation; and (2) several sublethal cellular insults, including telomere shortening, DNA damage, mitochondrial dysfunction, d”
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “Chemotherapy can induce senescence (Ewald et al., 2010), and we therefore determined whether therapeutic removal of senescence could influence chemotoxicity.”
The Role of Autophagy in Cancer: Therapeutic Implications (2011, background): “and p27) in metabolically viable cells (37).”
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies (2020, background): “The DNA damage response ultimately activates one or several tumor suppressors pathways [p53, p16 (Ink4a), p21 (Waf1), and retinoblastoma (RB)], that trigger and maintain the senescence growth arrest (504).”