Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis

By M. Castellone, H. Teramoto, B. Williams, K. Druey, J. Gutkind. Science, 2005

960 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/31c3a2f4a15b7208ae7a20a46af8d5cef04837e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Paul Polakis
2. Eléonore Beurel
3. R. Moon
4. R. Jope
5. G. Schulte
6. J. Petersen
7. L. Bonewald
8. J. Dijksterhuis

In Pharmacology

1. C. Harris
2. Dingzhi Wang
3. R. Dubois

Citations in the corpus

• Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. (2008, background): “Supporting this notion, upon binding to its specific receptor, EP2, PGE2 activated the Wnt/β-catenin axis in colon cancer cells through the phosphoinositide 3–kinase/Akt-G protein αs-axin signaling axis resulting in the promotion of cell growth (26).”
• Wnt signaling in cancer. (2012, background): “Mechanistic proposals for the interaction between prostaglandin and Wnt signaling include COX2 as a direct target gene of Wnt signaling, PPARDelta as a convergent focal point for the two pathways, and stimulation of the Wnt pathway by crosstalk from the EP2 prostaglandin receptor (Araki et al. 2003;”
• Inflammation and cancer: An ancient link with novel potentials (2007, background): “119) and activate the Wnt pathway.(120) An elevated expression of COX2 is frequently reported in a variety of different human cancer and has been localized in both tumor epithelial cells and stroma supporting autonomous as well as landscaping effects in tumor development (reviewed in Ref.”
• Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases (2014, background): “In contrast, Gαs displaces GSK3 from Axin, an action that inhibits the GSK3mediated phosphorylation of β-catenin (Castellone et al., 2005).”
• Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration (2009, positive): “The connection between Wnt and PGE2 has been mechanistically described in cellular proliferation and oncogenesis (Castellone et al., 2005; Shao et al., 2005).”
• Osteocytes, mechanosensing and Wnt signaling. (2008, background): “Castellone et al (22) have shown that the PGE2 mediated group of colon cancer cells was through a Wnt/β-catenin pathway crosstalk mechanism.”
• The Role of COX-2 in Intestinal Inflammation and Colorectal Cancer (2009, positive): “PGE2 also activates canonical Wnt signaling by activating Tcf-4 transcription factors by stabilizing b-catenin in CRC cells (Castellone et al., 2005).”
• Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “These observations have led to the use of nonsteroidal antiinflammatory drugs that inhibit the protumorigenic effects of cyclooxygenase-2 and its metabolite prostaglandin E2, for the prevention of colon cancer (Brown and DuBois, 2005; Castellone et al., 2005).”