BDNF regulates eating behavior and locomotor activity in mice

By S. Kernie, D. Liebl, L. Parada. EMBO Journal, 2000

837 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/3141e4ee5a184095d900f2868110a1d923ab44aa

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Endocrine and Autonomic Systems

Citations in the corpus

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “In addition, this line of mice shows heightened locomotor activity (Kernie et al., 2000) as well as potentiated locomotor responses to amphetamine treatment (Dluzen et al., 2001; Saylor and McGinty, 2008), potentially implicating a lower threshold for psychosis-like behavior.”
The Influence of Exercise on Cognitive Abilities (2013, neutral): “is involved in energy metabolism (101, 115).”
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes (2007, positive): “The role of BDNF in metabolism is supported by studies on BDNF-deficient mice (Bdnf ), which develop hyperphagia and obesity in early adulthood [10].”
Brain foods: the effects of nutrients on brain function (2008, neutral): “In turn, BDNF has also been shown to influence multiple parameters of energy metabolism, such as appetite suppressio”
Brain-derived neurotrophic factor. (2004, background): “…fail to survive past 3 weeks, but heterozygous BDNF knockout (þ /2 ) mice are viable, and exhibit a variety of phenotypes, including obesity (Lyons et al., 1999; Kernie et al., 2000), decreased seizure susceptibility (Kokaia et al., 1995) and impaired spatial learning (Linnarsson et al., 1997).”
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor (2003, background): “Obesity phenotypes have been observed in BDNF heterozygous mice and in mice in which the BDNF gene has been deleted in excitatory neurons in the brai”
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. (2000, background): “Young adults (in which the induction of LTP is compromised) show learning deficits (Linnarsson et al. 1997) and, although they have a normal life span, they develop an enhanced aggressiveness and hyperphagia, accompanied with weight gain in early adulthood (Lyons et al. 1999; Kernie et al. 2000).”
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, background): “…et al., 1997; Cosgaya et al., 2002; Carter et al., 2003), BDNF exhibits survival and synaptic actions in adulthood with distinct behavioral effects on memory, food intake and energy balance, and mood (Lyons et al., 1999; Kernie et al., 2000; Hariri et al., 2003; Xu et al., 2003; Pang et al., 2004).”
Impact of intermittent fasting on health and disease processes (2016, neutral): “Similar to leptin-deficient mice and leptin receptor mutant mice, mice with reduced BDNF levels are hyperphagic and develop insulin resistance and diabetes (Kernie et al., 2000).”
Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. (2001, background): “It is also improbable that BDNF acts directly to inhibit expression of POMC, as this would result in an increase in food intake, and this and other reports show that BDNF inhibits eating (3, 4, 35).”
Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice (2008, methodology): “…using an established method to identify the subset of mutant mice within the normal weight range (within 2 SDs of the wild-type mouse weight) (Kernie et al., 2000), we found that this subgroup of BACHD mice performed comparable with those BACHD mice with weight gain, and both subgroups…”
Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “In the absence of normal levels of BDNF, mice show enhanced aggressiveness, hyperactivity and hyperphagi”
Brain-derived neurotrophic factor and its clinical implications (2015, background): “BDNF reduced hepatomegaly present in db/db mice, reduced liver glycogen and reduced liver enzyme activity in serum, supporting the involvement of liver tissue in the mechanism of action of BDNF [99, 100].”