Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity.
By M. Rios, G. Fan, C. Fekete, J. Kelly, B. Bates, Ralf Kühn, R. Lechan, R. Jaenisch. Molecular Endocrinology, 2001
808 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Surgery
View Paper: https://www.semanticscholar.org/paper/995b0a35b0ea8ce97e930b1388b3db1de41c1750
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In Cellular and Molecular Neuroscience
In Endocrine and Autonomic Systems
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Citations in the corpus
- Brain-derived neurotrophic factor. (2004, background): “Trk signalling is now thought to include retrograde transport of intact neurotrophin–trk complexes to the neuronal cell body (Miller and Kaplan, 2001; Ginty and Segal, 2002).”
- Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, neutral): “(Dellovade et al., 2000) and are obese (Majdic et al., 2002); (3) the expression of brain-derived neurotrophic factor (BDNF), the deficiency of which causes obesity ( Rios et al., 2001 ), is nutritionally regulated in the VMH (Xu et al., 2003); and (4) LEPRs are abundantly expressed in the VMH (Elmq”
- TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, result): “Previous studies with BDNF mutants regarding these anxiety- and depression-like behaviors have yielded mixed results: some were normal (Gorski et al., 2003; Monteggia et al., 2004; Saarelainen et al., 2003) while others were not (Chen et al., 2006; Monteggia et al., 2007; Rios et al., 2001).”
- Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “In the absence of normal levels of BDNF, mice show enhanced aggressiveness, hyperactivity and hyperphagi”
- Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “By contrast, heterozygous deletion of the BDNF gene results in chronic hyperphagia with resulting age-dependent obesity, hyperinsulinaemia and hyperglycaemi”
- Microglia promote learning-dependent synapse formation through BDNF (2013, methodology): “To test this possibility, we crossed CX3CR1 CreER mice with mice containing a floxed allele of BDNF (BDNF) (Rios et al., 2001) to remove BDNF from microglia.”
- Brain-derived neurotrophic factor and its clinical implications (2015, background): “BDNF reduced hepatomegaly present in db/db mice, reduced liver glycogen and reduced liver enzyme activity in serum, supporting the involvement of liver tissue in the mechanism of action of BDNF [99, 100].”
- Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor (2003, background): “Obesity phenotypes have been observed in BDNF heterozygous mice and in mice in which the BDNF gene has been deleted in excitatory neurons in the brai”