Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

By Baoji Xu, Evan H. Goulding, K. Zang, D. Cepoi, Roger Cone, K. R. Jones, L. Tecott, L. Reichardt. Nature Neuroscience, 2003

907 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/4e8cdaf427cef25c6baeca3c29d1fe476dfff154

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Bradford B. Lowell
2. S. O’Rahilly
3. C. Ye
4. I. S. Farooqi
5. A. Coll
6. J. Elmquist

In Nutrition and Dietetics

1. Bradford B. Lowell
2. S. O’Rahilly
3. I. S. Farooqi
4. Undurti N. Das
5. A. Coll
6. J. Elmquist

In Physiology

1. Bradford B. Lowell
2. S. O’Rahilly
3. S. Farooqi

Citations in the corpus

• Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity (2017, background): “Interestingly, genome-wide association studies in humans have revealed a robust association of single nucleotide polymorphisms (SNPs) with excess weight and obesity, not only in or near to the BDNF gene (for a review, see Xu and Xie, 2016) but also in intron 1 D is ea se M o d el s & M ec h an is m ”
• Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, positive): “Recent studies have raised the possibility of an important role for BDNF in the VMH ( Xu et al., 2003 ).”
• The Hormonal Control of Food Intake (2007, positive): “An exciting study reported that MC4R and BDNF/TRk-B-mediated signaling may be coupled in the regulation of energy balance (Xu et al., 2003).”
• Brain foods: the effects of nutrients on brain function (2008, neutral): “In addition, the hypothalamic melanocortin 4 receptor, which is crucial for the control of energy balance, regulates the expression of BDNF in the ventral medial hypothalamu”
• Brain-derived neurotrophic factor and its clinical implications (2015, background): “Furthermore, BDNF and IGF-I have similar downstream signaling mechanisms, incorporating both p-CAMKII (calcium/calmodulin protein kinase II) and p-MAPKII (phosphorylated mitogen-activated protein kinase II) signaling cascades [107, 108], which promote cell survival by a dual mechanism consisting of”
• Brain-derived Neurotrophic Factor Promotes Differentiation and Maturation of Adult-born Neurons Through GABAergic Transmission (2012, methodology): “Emily G. Waterhouse,1 Juan Ji An,1 Lauren L. Orefice,1 Maryna Baydyuk,1 Guey-Ying Liao,1 Kang Zheng,2 Bai Lu,2 and Baoji Xu1 1Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057 and 2Gene, Cognition and Psychosis”
• ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, background): “…et al., 1997; Cosgaya et al., 2002; Carter et al., 2003), BDNF exhibits survival and synaptic actions in adulthood with distinct behavioral effects on memory, food intake and energy balance, and mood (Lyons et al., 1999; Kernie et al., 2000; Hariri et al., 2003; Xu et al., 2003; Pang et al., 2004).”
• Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “BDNF also modulates hypothalamic metabolic function, further reflecting the diversity of its role in the adult brai”
• Neurotechnique A Chemical-Genetic Approach to Studying Neurotrophin Signaling (2005, neutral): “Although less well characterized, neurotrophins also appear to control many aspects of central nervous system (CNS) development and modulate synaptic plasticity, metabolism, and neurotransmission in the adult nervous system (for examples, see Guillin et al., 2001; McAllister et al., 1999; Xu et al.,”
• Brain-derived neurotrophic factor. (2004, background): “TrkA binds NGF (with low-affinity binding by NT-3 in some systems); trkB binds BDNF and NT-4/5 with lower- affinity binding by NT-3; and trkC binds NT-3 (Barbacid, 1994).”
• Distinct Role of Long 3′UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons (2008, neutral): “In situ hybridization of brain sections was performed according to a protocol adapted from previously described procedures (Muddashetty et al., 2007; Tongiorgi et al., 1998; Xu et al., 2003).”
• Genetics of obesity in humans. (2006, background): “Recently, BDNF has been implicated in the regulation of body weight because its expression is reduced by fasting (61) and BDNF administration causes weight loss in wild-type mice through a reduction in food intake.”