Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
By J. Vriens, Hiroyuki Watanabe, Annelies Janssens, G. Droogmans, T. Voets, B. Nilius. Proceedings of the National Academy of Sciences of the United States of America, 2003
626 citations recorded by the source corpus.
Subfields: Physiology, Pulmonary and Respiratory Medicine, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/313d86c5e9787b21c1b001b5988f339a94a0386d
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In Physiology
In Sensory Systems
- Ardem Patapoutian
- Veena Viswanath
- A. Dhaka
- C. Montell
- M. Delling
- Ramsey Delling Clapham
- I. S. Ramsey
- D. Clapham
Citations in the corpus
- Mechanisms of sensory transduction in the skin (2007, background): “As with OSM-9, the osmotic activation of TRPV4 requires fatty acid metabolite”
- An introduction to TRP channels. (2006, background): “TRPV4 is a constitutively active Ca2+-permeable cation channel that displays a gently outwardly rectifying I-V relation in response to moderate heating, hypotonic challenge, or the phorbol ester 4α-PDD (8, 99).”
- The TRP Superfamily of Cation Channels (2005, background): “esters, but not by cell swelling or arachidonic acid (127).”
- NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels (2005, background): “There is some evidence that Src family kinases may regulate members of the TRP family (Xu et al, 2003; Jin et al, 2004; but see Vriens et al, 2004).”
- Trp ion channels and temperature sensation. (2006, background): “This same domain is involved in capsaicin binding to TRPV1 and is critical for activation of TRPV4 by 4αPDD, indicating at least a partial conservation of ligand activation of thermoTRPs ( Jordt & Julius 2002, Vriens et al. 2004).”