Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages

By N. Ouchi, S. Kihara, Y. Arita, M. Nishida, A. Matsuyama, Y. Okamoto, M. Ishigami, H. Kuriyama, Ken-ichi Kishida, H. Nishizawa and 6 more. Circulation, 2001

1,204 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/30b034abe1ebf694bf213be4d7ea218ae8127eb6

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In Epidemiology

1. P. Scherer
2. Haiming Cao
3. K. Walsh
4. M. Trujillo
5. N. Ouchi
6. Takashi Kadowaki
7. Toshimasa Yamauchi
8. H. Fang

In Immunology

1. P. Scherer
2. G. Hotamisligil
3. H. Fang
4. R. L. Judd

Citations in the corpus

• Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. (2004, background): “In addition, adiponectin negatively regulates myelomonocytic progenitor cell growth and TNF- production in macrophages (102).”
• Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “Adiponectin concentrations are reduced in patients with coronary artery disease (9), and adiponectin inhibits tumor necrosis factor (TNF- )-induced expression of adhesion molecules and the transformation of macrophages to foam cells, both of which are key components of atherogenesis (15, 16).”
• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “[47] Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, et al.”
• Adiponectin: A novel adipokine linking adipocytes and vascular function. (2004, neutral): “Additional antiinflammatory effects of adiponectin (fAd) include suppression of leukocytic colony formation, reduction of phagocytic activity, and reduction of TNF secretion from macrophages (34, 36).”
• Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. (2003, background): “Adiponectin inhibits foam cell formation from macrophages by reducing the expression of class A macrophage scavenger receptor and lipid accumulation (23).”
• Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400373-JLR200 (2005, background): “In addition, adiponectin may inhibit both the inflammatory process and atherogenesis by suppressing the migration of monocytes/macrophages and their transformation into foam cells in the vascular wall (14, 15 ).”
• The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. (2003, neutral): “Adiponectin has antiatherogenic activity (54, 55), whereas TNF-α contributes to the onset of atherosclerosis (56).”
• Plasma adiponectin levels and risk of myocardial infarction in men. (2004, background): “21 It was shown that adiponectinbindstosubendothelialcol-lagensandsuppressesproliferationand migrationofhumanaorticsmooth musclecells.”