Mast cells are essential intermediaries in regulatory T-cell tolerance

By Li-Fan Lu, E. Lind, David C. Gondek, Kathy A. Bennett, M. Gleeson, Karina Pino-Lagos, Zachary A. Scott, A. Coyle, J. Reed, J. Snick and 3 more. Nature, 2006

796 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/30865e1250a219be60a18e587dbb98e6dd77197c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. W. E. Paul
2. Jinfang Zhu
3. S. Galli
4. V. Kuchroo
5. M. Tsai
6. S. Bischoff
7. J. Kalesnikoff
8. M. Oukka

In Physiology

1. S. Galli
2. M. Tsai
3. J. Kalesnikoff
4. G. Anderson
5. S. Bischoff

Citations in the corpus

• Immunomodulatory mast cells: negative, as well as positive, regulators of immunity (2008, background): “Mast cells also contribute to two other models of immunosuppressio”
• Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data (2007, background): “As a result, mast cells have been recognized in the past decade as cells that not only regulate allergy, but also many tissue functions, such as blood flow and coagulation, smooth-muscle contraction and peristalsis of the intestine, mucosal secretion, wound healing, regulation of innate and adaptive”
• New developments in mast cell biology (2008, background): “and in peripheral tolerance to skin allografts (which requires the participation of CD4 + CD25 + Foxp3 + regulatory T cells”
• Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “IL-9 production can also be induced in Th17 and Treg cells (187, 188) whose differentiation also involves TGFb, suggesting a transcription factor that is responsible for IL-9 production such as PU.”
• Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3− effector T cells that produce interleukins 9 and 10 (2008, background): “However, IL-9 is also produced by T reg cells themselve”
• How cigarette smoke skews immune responses to promote infection, lung disease and cancer (2009, background): “Exposure to cigarette smoke attenuates the cytotoxic activity and cytokine production of NK cells in humans and mic”
• Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils (2011, neutral): “On the basis of evidence derived mainly from c-Kit-deficient mice, mast cell have also been linked to the promotion of peripheral tolerance to skin graft”