A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
By Xin Zeng, K. Tamai, B. Doble, Shitao Li, He Huang, Raymond Habas, H. Okamura, J. Woodgett, Xi He. Nature, 2005
897 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/3055182ff7ca43ae81627b375408f91991e3d105
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In Molecular Biology
- Eléonore Beurel
- B. Doble
- S. Grieco
- W. Birchmeier
- R. Jope
- J. Woodgett
- Alexandra Klaus
- Christof Niehrs
In Oncology
Citations in the corpus
- Wnt/beta-catenin signaling in development and disease. (2006, neutral): “Recent studies have indicated that the coreceptor LRP5/6 interacts with Axin through five phosphorylated PPP(S/T)P repeats in the cytoplasmic tail of LRP (Davidson et al., 2005; Zeng et al., 2005).”
- Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Upon Wnt-Fz interaction, Lrp6 becomes phosphorylated by Casein kinase 1g, which allows Axin to bind to Lrp6 (Davidson et al., 2005; Zeng et al., 2005).”
- Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases (2014, background): “Other receptors reported to be phosphorylated by GSK3 include the androgen receptor, which reduces its activation of transcription (Salas et al., 2004; Wang et al., 2004), the prolactin receptor, which targets it for proteasomal degradation (Plotnikov et al., 2008), the progesterone receptor, which ”
- Wnt signaling in development and tissue homeostasis (2018, background): “…and the Cdk14(PFTK1)-Cyclin Y mitotic kinase complex (Davidson et al., 2009) then phosphorylate PPPSP motifs within the intracellular region of LRP5/6, thereby priming them for further phosphorylation by the membrane-anchored kinase casein kinase 1 γ (Davidson et al., 2005; Zeng et al., 2005).”
- Wnt signaling: is the party in the nucleus? (2006, background): “Binding of Wnt ligands induces phosphorylation of the LRP5/6 intracellular domain through the combined actions of CK1 , a membrane-tethered kinase, and GSK3 (Davidson et al. 2005; Zeng et al. 2005).”