Adult mesenchymal stem cells and cell-based tissue engineering

By Rocky S. Tuan, G. Boland, R. Tuli. Arthritis Research & Therapy, 2002

827 citations recorded by the source corpus.

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs, including their differentiation potentials in vitro and in vivo, and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types, such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions.

Subfields: Genetics, Surgery, Urology

View Paper: https://www.semanticscholar.org/paper/2ff9979434be6eba4043f9680a9c597609df81d9

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Citations in the corpus

Stem cell-based tissue engineering with silk biomaterials. (2006, background): “These cells also have the potential for a wide range of therapeutic applications through autologous, allogeneic or xenogeneic stem cell transplantation [132,133].”
3D Bioprinting for Engineering Complex Tissues (2015, methodology): “Inkjet bioprinting was the ﬁ rst bioprinting technology (Tuan et al., 2003) and is very similar to conventional 2D inkjet printing (Singh et al., 2010).”
Bioprinting Toward Organ Fabrication: Challenges and Future Trends (2013, background): “(ESCs) [57], adult stem cells (ASCs) [59], most recently, induced pluripotent stem (iPS) cells [60], and tissue-specific cell lines [61], [62].”
Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration (2007, background): “To date, many of the studies on ES cells have been limited to mouse models, since human cell lines have only recently become available (Tuan et al. 2002).”
Engineering Complex Tissues (2006, neutral): “, growth factors) required for tissue-specific differentiation have been elucidated.(16) In the case of embryonic stem cells (ESCs), manipulating or controlling differentiation remains a significant challenge.”
Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation (2007, positive): “Recombinant proteins and/or adenoviral infection of MSCs with TGF-β1 and TGF-β3, BMP-2, BMP-4, BMP-6 [35], BMP-12 [36], BMP-13 [37], and GDF-5 have been shown to rapidly induce chondrogenesis of MSCs from a variety of mesodermal tissue sources (reviewed in [31]).”
Electrospinning of Polymeric Nanofibers for Tissue Engineering Applications: A Review (2006, positive): “Electrospun scaffolds have been shown to support the attachment and proliferation of MSCs. 78 Bone marrow-derived human MSCs seeded onto nanofiber PCL scaffolds are able to differentiate into adipogenic, chondrogenic, or osteogenic lineages based upon the culture media selected.”
Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy (2004, background): “[16]), and human umbilical cord perivascular cells derived from the Wharton’s Jelly [17], suggesting that the MSC niche may not be restricted to just bone marrow.”