Bioprinting Toward Organ Fabrication: Challenges and Future Trends

By Ibrahim T. Ozbolat, Yin Yu. IEEE Transactions on Biomedical Engineering, 2013

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3D Bioprinting for Engineering Complex Tissues (2015, background): “For clinical applications, cells for bioprinting would ideally be isolated from the patients themselves to avoid negative immune responses (Ozbolat and Yu 2013).”
3D printing of smart materials: A review on recent progresses in 4D printing (2015, background): “Moreover, the current tissue engineering technology has a few major limitations such as non-automated manipulation, small manufacturing scale, inability to produce complex 3D organs and non-ordered and weak tissue microstructure (Ozbolat and Yu 2013, Chua and Yeong 2015).”
A comprehensive review on droplet-based bioprinting: Past, present and future. (2016, background): “Different bioprinting modalities, including DBB, are envisioned to fabricate functional replacement human organs in the future [10,138]; however, several challenges have yet to be overcome to make it a reality.”
3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances (2018, background): “The main reason for that is the inherent inability of printing head to provide a continuous flow which limits its application in bioprinting [8].”
Current advances and future perspectives in extrusion-based bioprinting. (2016, background): “In addition, parenchymal cells in highly metabolic organs do not secrete many ECM components, and the resulting cell aggregates are very weak in mechanical and structural integrity [174].”