3D Bioprinting for Engineering Complex Tissues
By Christian J Mandrycky, Zongjie Wang, Keekyoung Kim, Deok‐Ho Kim. Biotechnology Advances, 2015
1,536 citations recorded by the source corpus.
Bioprinting is a 3D fabrication technology used to precisely dispense cell-laden biomaterials for the construction of complex 3D functional living tissues or artificial organs. While still in its early stages, bioprinting strategies have demonstrated their potential use in regenerative medicine to generate a variety of transplantable tissues, including skin, cartilage, and bone. However, current bioprinting approaches still have technical challenges in terms of high-resolution cell deposition, controlled cell distributions, vascularization, and innervation within complex 3D tissues. While no one-size-fits-all approach to bioprinting has emerged, it remains an on-demand, versatile fabrication technique that may address the growing organ shortage as well as provide a high-throughput method for cell patterning at the micrometer scale for broad biomedical engineering applications. In this review, we introduce the basic principles, materials, integration strategies and applications of bioprinting. We also discuss the recent developments, current challenges and future prospects of 3D bioprinting for engineering complex tissues. Combined with recent advances in human pluripotent stem cell technologies, 3D-bioprinted tissue models could serve as an enabling platform for high-throughput predictive drug screening and more effective regenerative therapies.
Subfields: Automotive Engineering, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/b44e8c5a87c8c11ccdec76fc4d4c858ae97fa66a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Automotive Engineering
In Biomedical Engineering
Citations in the corpus
- Progress in 3D bioprinting technology for tissue/organ regenerative engineering. (2020, background): “Developing living functional tissues by artificial means can address an unmet need in tissue replacement and organ transplantation [2,3].”
- An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects (2018, background): “This scaffold-free technique has very high cell viabilities (>95 [54]) and a resolution between 10–50 μm [1].”
- Applications of Alginate-Based Bioinks in 3D Bioprinting (2016, background): “The uses of these 3D functional living tissues range from basic research [2] (i.”
- The Emerging Frontiers and Applications of High-Resolution 3D Printing (2017, background): “With a combination of 3D printing microfluidic devices and tissues in a single-step fabrication process, organs-on-chips would be far more cost-effective and productive, and thus has emerged as a promising alternative to animal studies and conventional cell cultures for biomedical research [32,105].”