Leptin-regulated endocannabinoids are involved in maintaining food intake

By V. Di Marzo, S. Goparaju, Lei Wang, Jie Liu, S. Batkai, Z. Járai, F. Fezza, Grant I. Miura, R. Palmiter, T. Sugiura and 1 more. Nature, 2001

1,601 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2f583e32c6d8422c0c1e17b8c6c22536fba00ae4

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Citations in the corpus

The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. (2003, background): “Recently, a role for the cannabinoid receptor subtype 1 (CB1-R) in the regulation of appetite and body weight has been reported (Di Marzo et al., 2001).”
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. (2003, background): “Importantly, the levels of hypothalamic endocannabinoids were shown to be decreased after leptin administration, and the blockade of CB1 was demonstrated to inhibit starvation-induced hyperphagia in mice (17).”
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors (2002, background): “O-1812 also possesses a 1 (cid:1) -methyl substituent, and it too appears to lack significant susceptibility to hydrolysis by FAAH (Di Marzo et al., 2001a).”
Multiple neural systems controlling food intake and body weight. (2002, background): “Interestingly, cannabinoid receptors have been preserved in mammalian species [81] and the newly discovered endogenous ligands (endocannabinoids) can affect food intake in rats and mice [69].”
Pharmacokinetics and Pharmacodynamics of Cannabinoids (2003, background): “Tonic activity has also been demonstrated with regard to appetite control[166] and with regard to vomiting in emetic circuits of the brain.”
The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, unknown): “targeted by endocannabinoid action (58, 294).”
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. (2005, background): “Sites in the hypothalamus (4, 10, 12), limbic forebrain (11–13), and peripheral sensory nerve terminals (7) have been implicated in mediating the orexigenic effect of endocannabinoids, which is potentiated by hunger or in hyperphagia associated with obesity (4–6, 9) and antagonized by CB1 blockade.”
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. (2006, background): “For example, leptin controls the levels of anandamide through regulation of FAAH, and of 2-AG through regulation of the levels of its biosynthetic precursor (7, 23, 24).”
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol (2007, background): “Endocannabinoid signaling has been found to modulate a number of physiological processes, including pain sensation [3], appetite [4], and cognitive and emotional state [5, 6].”
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain (2003, background): “…context, there is a growing interest in 2-AG/CB1 signaling in terms of therapies for a range of conditions including neurodegenerative diseases (Di Marzo et al., 2000; Panikashvili et al., 2001), obesity (Di Marzo et al., 2001), and the extinction of aversive memories (Marsicano et al., 2002).”