Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.

By I. Matias, Marie‐Paule Gonthier, P. Orlando, V. Martiadis, L. De Petrocellis, C. Cervino, S. Petrosino, L. Hoareau, F. Festy, R. Pasquali and 5 more. Journal of Clinical Endocrinology and Metabolism, 2006

682 citations recorded by the source corpus.

Subfields: Pharmacology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/8549efd0f6d97493ddb9032110b1b373a88f8c02

How researchers see this paper

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In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. George Kunos
4. R. Ross
5. P. Pacher
6. S. Batkai
7. R. Mechoulam
8. K. Mackie

In Physiology

1. Patrice D Cani
2. N. Delzenne
3. F. Bäckhed
4. J. Despres
5. André Tchernof
6. R. Ross
7. P. Pacher
8. Rob Knight

In Surgery

1. J. Despres
2. André Tchernof
3. F. Bäckhed
4. Patrice D Cani
5. P. Pacher
6. S. Batkai
7. George Kunos
8. R. Pertwee

Citations in the corpus

• The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “An up-regulation of CB1 receptors has been also reported in adipose tissue of genetically obese compared with lean mice (Bensaid et al., 2003), and elevated endocannabinoid levels have been detected in adipose tissue of obese compared with lean patients (Matias et al., 2006).”
• Pathophysiology of human visceral obesity: an update. (2013, background): “Adipose tissue expresses CB1 receptors, and endocannabinoids have been detected in both subcutaneous and visceral adipose tissue in humans (358).”
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, background): “For example, 24 h of activation of PPAR by ciglitazone decreased levels of 2-AG, but not anandamide, in immature, but not mature, 3T3 F442A mouse adipocytes (Matias et al., 2006).”
• The endocannabinoid system links gut microbiota to adipogenesis (2010, background): “…adipogenesis Given that obesity is characterised by the dysregulation of eCB system tone in adipose tissue (Engeli et al, 2005; Bluher et al, 2006; Matias et al, 2006; Cote et al, 2007; D’Eon et al, 2008; Starowicz et al, 2008; Di Marzo et al, 2009; Izzo et al, 2009), we investigated this…”
• Targeting the endocannabinoid system: to enhance or reduce? (2008, background): “, or, given the antilipolytic action of CB 1 receptor”